Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study.

Background: Women with polycystic ovary syndrome (PCOS) are at a high risk to develop Gestational Diabetes mellitus (GDM). We hypothesized that metformin due to its metabolic, endocrine, vascular, and anti-inflammatory effects may reduce the incidence of GDM in PCOS women.

Patient And Method: We carried out a prospective cohort study to determine the beneficial effects of metformin on PCOS patients during pregnancy.

Clinical outcome following stimulation with HMG versus highly purified HMG in patients undergoing ICSI.

Current purification processes allow the production of highly purified human menopausal gonadotrophin (HP-HMG), with human chorionic gonadotrophin (HCG) constituting most of its LH-like activity. This retrospective study aimed to compare the effectiveness of HP-HMG to the widely used traditional human menopausal gonadotrophin (HMG) preparation. A total of 174 women undergoing intracytoplasmic sperm injection cycles were allocated to either HMG or HP-HMG for ovarian stimulation.

Chemical activation of oocytes in different types of sperm abnormalities in cases of low or failed fertilization after ICSI: a prospective pilot study.

This study evaluated the influence of chemical activation of oocytes in cases with abnormal sperm morphology and previous low intracytoplasmic sperm injection (ICSI) fertilization rate. Fertilization, early cleavage and embryo quality were assessed according to individual abnormal sperm morphology with or without chemical activation of oocytes after ICSI in 56 consecutive cycles with different types of abnormal sperm morphology (A = amorphous head, B = tapered head, C = bent neck) having a history of previous failed or low fertilization rate. Chemical activation significantly increased fertilization rate in subgroup A (82.

Metformin reduces abortion in pregnant women with polycystic ovary syndrome.

Background: Women with polycystic ovary syndrome (PCOS) are considered to be at increased risk of miscarriage. Since metformin has beneficial effects on the risk factors contributing to first-trimester abortion in PCOS patients, we hypothesized that metformin - owing to its metabolic, endocrine, vascular and anti-inflammatory effects - may reduce the incidence of first-trimester abortion in PCOS women.

Materials And Methods: A prospective cohort study was set up to determine the beneficial effects of metformin on PCOS patients during pregnancy.