Publications by authors named "I Abdulkadir"
Background: Methicillin-Resistant (MRSA) is both a human commensal and a pathogen that causes neonatal infection which is associated with significant morbidity and mortality. Its genetic flexibility and versatility have equipped it with the ability to develop resistance to numerous antibiotics. Outbreaks of infections in neonatal intensive care units as well as community infections have been reported mostly in developed countries.
View Article and Find Full Text PDFBackground: The use of antenatal corticosteroids beyond 34 weeks of gestation to prevent certain neonatal complications remains a debate. This study sought to determine the effect of the use of antenatal corticosteroids in late preterm delivery on neonatal morbidity.
Methodology: It was a randomized double-blind placebo and active-controlled multi-arm trial.
Article Synopsis
- Preterm and very low birthweight (VLBW) infants face high health risks in their early days, with full enteral feeding being crucial for their care, especially in sub-Saharan Africa where data on feeding practices is limited.
- This study analyzed demographic and clinical data from 484 preterm and VLBW infants across 7 neonatal units in Nigeria and Kenya to assess factors affecting the time to achieve full enteral feeds.
- Results indicated a significant percentage of mortality before feeding, revealing that earlier first feeds and gestational age greatly influenced the time to reach full enteral feeds, suggesting that implementing standardized feeding guidelines could improve outcomes in these infants.
Nanoscale materials have demonstrated a very high potential in anticancer therapy by properly adjusting their functionalization and physicochemical properties. Herein, we report the synthesis of some novel vanadocene-loaded silica-based nanomaterials incorporating four different S-containing amino acids (penicillamine, methionine, captopril, and cysteine) and different fluorophores (rhodamine B, coumarin 343 or Alexa Fluor™ 647), which have been characterized by diverse solid-state spectroscopic techniques viz; FTIR, diffuse reflectance spectroscopies,C andV solid-state NMR spectroscopy, thermogravimetry and TEM. The analysis of the biological activity of the novel vanadocene-based nanostructured silicas showed that the materials containing cysteine and captopril aminoacids demonstrated high cytotoxicity and selectivity against triple negative breast cancer cells, making them very promising antineoplastic drug candidates.
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