Publications by authors named "I A Zonnenberg"
Background: Physiological-based cord clamping (PBCC) in preterm infants is beneficial for cardiovascular transition at birth and may optimize placental transfusion. Whether PBCC can improve clinical outcomes is unknown. The aim of the Aeration, Breathing, Clamping (ABC3) trial was to test whether PBCC results in improved intact survival in very preterm infants.
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- The ABC3 trial investigates the potential benefits of physiological-based cord clamping (PBCC) compared to standard time-based cord clamping (TBCC) for very preterm infants, aiming to reduce complications like cerebral injury and necrotizing enterocolitis (NEC).
- It is a multicenter, randomized clinical trial involving infants born before 30 weeks of gestation, assessing outcomes such as intact survival and short-term co-morbidities during NICU admission.
- The results of this study will inform future clinical guidelines regarding optimal cord clamping practices at birth to enhance infant health outcomes.
Background: Apnoea of prematurity (AOP) is one of the most common diagnoses among preterm infants. AOP often leads to hypoxemia and bradycardia which are associated with an increased risk of death or disability. In addition to caffeine therapy and non-invasive respiratory support, doxapram might be used to reduce hypoxemic episodes and the need for invasive mechanical ventilation in preterm infants, thereby possibly improving their long-term outcome.
View Article and Find Full Text PDFBackground: International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to lung aeration may severely limit circulatory adaptation resulting in a reduction in cardiac output and hypoxia. Delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) allows for an adequately established pulmonary circulation and results in a more stable circulatory transition.
View Article and Find Full Text PDFShort-term pulmonary and systemic effects of hydrocortisone initiated 7-14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial.
Arch Dis Child Fetal Neonatal Ed
January 2023
Objective: Observational studies in preterm infants suggest that systemic hydrocortisone improves pulmonary condition but may also lead to systemic adverse effects. We report the short-term pulmonary and systemic effects of hydrocortisone initiated in the second week.
Design: Randomised placebo-controlled trial.