Human bone marrow granulocyte-macrophageal colonies (GM-Cs) in vitro: myeloid cells in health and in cases of myeloid leukemia.

The morphological characteristics of granulocyte/macrophageal (GM-) colonies and clusters, obtained in vitro (in semi-solid agar cultures) from bone marrow hematopoietic myeloid progenitors pertain to leukocyte hemorheology of healthy persons and patients with myeloid leukemias. The morphological features of in vitro growing myeloid progenitors, granulocytes and macrophages of healthy persons differ in their cell size, shape and degree of differentiation from the cultivated marrow cells in cases of acute and chronic myeloid leukaemia. In this malignant disease, the rheological properties of leukocytes (granulocytes/macrophages) were found to provide diagnostic information.

[Choice of the anti-arrhythmia drug and antitachycardia pacemakers in persistent tachycardias].

In 57 patients with recurrent tachycardiac attacks in whom the empiric medical drug treatment failed to prevent the attacks electrophysiological examination was carried out in order to specify the type of the tachycardia. This was followed up by a serial testing of drugs. In 41 patients an antiarrhythmic drug (or a combination of drugs) was found which could prevent the attacks.