Publications by authors named "I A Trifonova"
SARS-CoV-2 can trigger hyperinflammation, leading to severe COVID-19, presenting with pneumonia, acute respiratory distress syndrome (ARDS), and multiple organ failure. Specific biomarkers like leukocytes, CRP, NLR, AST, LDH, D-dimer, ferritin, and IL-6 are associated with disease severity. Anakinra, an IL-1 receptor antagonist, has been proposed to mitigate hyperinflammation, but its clinical efficacy remains uncertain.
View Article and Find Full Text PDFBackground: Mixed infections can worsen disease symptoms. This study investigated the impact of mixed infections with viral and bacterial pathogens in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: Using the in-house multiplex PCR method, we tested 337 SARS-CoV-2 positive samples for co-infections with three bacterial and 14 other viral pathogens.
Toscana virus (TOSV) is an arthropod-borne virus transmitted by sandflies and is mainly found in countries around the Mediterranean basin. In this article, we present the findings of a seroprevalence study on TOSV in Bulgaria. We aim to assess the current epidemiological situation regarding TOSV in the country and raise clinical awareness.
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- Lyme Borreliose (LB) is a tick-borne infection that is becoming more common in Bulgaria, identified as the leading tick-borne disease in the area.
- A study analyzed 1,892 serum samples to determine the seroprevalence of LB, finding an overall rate of 5.4%, with variations influenced by factors like age, sex, and whether individuals live in rural or urban settings.
- The results showed higher seroprevalence in older adults (8.4% in those over 65), males (8.4%), and rural residents (10.2%), emphasizing the need for better diagnostic methods and public health awareness in combating LB.
After two seasons of absence and low circulation, influenza activity increased significantly in the winter of 2022-2023. This study aims to characterize virological and epidemiological aspects of influenza infection in Bulgaria during the 2022-2023 season and perform a phylogenetic/molecular analysis of the hemagglutinin () and neuraminidase () sequences of representative influenza strains. Influenza A and B viruses generate new genetic groups/clades each season, replacing previously circulating variants.
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