[A trial of the use of a new thrombolytic preparation--recombinant tissue-type plasminogen activator--in myocardial infarct patients].

Search for more effective and safe drugs has recently led to the design of second-generation thrombolytic enzymes one of which is recombinant tissue plasminogen activator. A total of 80 patients including 41 who received tissue plasminogen activator (TPA) (Group 1), 39 on streptokinase (SK) (Group 2) were examined. By the 90th minute of thrombolytic infusion, coronary blood flow was recovered in 27 (66%) patients from Group 1 and 19 (49%) from Group 2 (p = 0.

[Effects of restoration of coronary circulation on the function of the left ventricle in patients with acute myocardial infarction (a follow-up after 1 year)].

Values of overall and local left ventricular function were studied in 89 patients in the acute period and 1 year following myocardial infarction. Three patient groups were identified: (1) 26 patients with coronary artery patency recorded by the first coronary angiography; (2) 20 with coronary blood flow recovery made by thrombolytic therapy; and (3) 40 with coronary occlusion. There was a significant improvement of left ventricular function in the patients from Group 1 during their hospital treatment and 1 year after.

[Possibilities of the use of 99mTc pyrophospate myocardial scintigraphy in the early period of myocardial infarct in the evaluation of the effectiveness of thrombolytic therapy].

In early (mean time, 6.9 +/- 0.2 hours following the onset of an anginal episode), 99mTc pyrophosphate myocardial scintigraphy was performed in 28 patients who received thrombolytic therapy under angiographic monitoring.

[Thrombolytic treatment of myocardial infarction at the prehospital and hospital stage].

Thrombolytic therapy was performed in 59 patients within the first hours of myocardial infarction. Twenty three patients (Group 1) were given streptokinase (SK) by an emergency team, 36 patients (Group 2) received SK following coronary angiography. In Group 1, SK was initiated earlier (p less than 0.

[An evaluation of left ventricular myocardial function by x-ray and electrocardiographic data in patients with postinfarct cardiosclerosis].

To determine the diagnostic significance of x-ray criteria for assessing heart function in patients with postinfarction cardiosclerosis, the coronary-ventricular and electrocardiographic findings were compared with x-ray data in patients of 2 age groups. Group I was made up of patients aged 22 to 39 years, group II of patients aged 60 to 69 years. An attempt was made to base the use of the x-ray method during follow-up of patients suffering from coronary disease.