[CHARACTERISTIC OF APOPTOSIS OF CORONARY ARTERY CELLS WITH ATHEROSCLEROTIC LESIONS].

Aim: To study apoptosis of endothelial cells (EC), macrophages (MF) and smooth muscle cells (SMC) in the early atherosclerotic process (prior to plaque formation), elucidate mechanisms of its realization and evaluate effect on progression of atherosclerosis.

Materials And Methods: Histopathological studies were performed on coronary arteries affected by atherosclerosis taken at autopsy of patients with coronary heart disease (n = 63). To detect apoptosis, the TUNEL method was used for calculating the apoptotic index (AI) in paraffin sections.

[Micromorphology of decayed tooth tissues covered with artificial crown].

Pathomorphological changes in dentine covered with artificial crown were studied in 40 decalcified teeth extracted from patients aged 35-61 years. The study of the decayed dentin microscopic structure revealed the uniform mineralization of dentinal tubules in 20% of cases, while in the absence of visually apparent caries it was present in 80% of cases. Irregular dentin structure was seen in 45% of caries cases and in 30% of observations with no signs of caries.

[Apoptosis cells of coronary artery wall as developing and progressing factor of coronary sclerosis].

Objective: To study apoptosis of individual cellular components of the vascular wall of coronary arteries at different morphological stages of atherosclerosis.

Material And Methods: The study was performed on coronary arteries taken from 52 deceased patients with atherosclerosis and coronary heart disease at different stages of atherogenesis. For morphological study prepared paraffin sections, which were stained for morphological studies were prepared paraffin sections, which were stained with hematoxylin and eosin, by Van Gieson, Masson, on lipids with Sudan black B, according to Van Cossu.

[Influence of hemicellulose based anticoagulant on male rat reproductive function].

Results of estimation of the effect of a new hemicellulose-based anticoagulant drug on the reproductive function of white male rats are presented. No negative impact on the fertility and breed was observed for the drug administered in doses of 5 and 25 mg/kg. However, in a dose of 50 mg/kg, the new drug negatively affected spermatogenesis and decrease the reproductive function of male rats.

[Cultured skin cells interaction with polylactide surface coated by different collagen structures].

The purpose of this work was an optimization of polylactide film surfaces designed for human keratinocytes cultivation. The polylactide films were coated by collagen 1. The experiments showed that uniform covering of polymer surface by collagen, and formation of different collagen structures depend on the mode of the protein application.