Ultraviolet Photodissociation and Activated Electron Photodetachment Mass Spectrometry for Top-Down Sequencing of Modified Oligoribonucleotides.

With the increased development of new RNA-based therapeutics, the need for robust analytical methods for confirming sequences and mapping modifications has accelerated. Characterizing modified ribonucleic acids using mass spectrometry is challenging because diagnostic fragmentation may be suppressed for modified nucleotides, thus hampering complete sequence coverage and the confident localization of modifications. Ultraviolet photodissociation (UVPD) has shown great potential for the characterization of nucleic acids due to extensive backbone fragmentation.

Biodiversity of Cav. in rice-growing regions of the south of Russia using PCR method.

The purpose of this research by the way of investigating the molecular genetic structure of a highly variable fungal phytopathogen Cav., to determine effective genes for the development of a strategy for immunogenetic protection against rice blast in conditions of epiphytotic development of the disease in the south of Russia, which would combine high efficacy with both environmental friendliness and resource and energy saving, to ensure country's food security. The knowledge of local pathotype diversity of Cav.

Luminescent diagnostics of skin defects in the near-infrared range.

Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control.

The Role of Concentration Dependent Static Permittivity of Electrolyte Solutions in the Debye-Hückel Theory.

The Debye-Hückel theory has been extended to allow for arbitrary concentration dependence of the electrolyte solution static permittivity. The theory follows the lines advanced by Erich Hückel ( Hückel, E. Phys.

[The biological evaluation of depression severity: a novel method for the determination of platelet serotonin concentration].

Objective: To develop a highly sensitive method for the determination of platelet-rich plasma serotonin concentration for every-day clinical practice.

Material And Methods: The method was developed for determination of serotonin in plateled-rich plasma. Serotonin was determined using high performance liquid chromatography with fluorescent detection and hematologic analyzer.