Publications by authors named "I A Seitz"
Purpose: Subretinal (SR) injection in porcine models is a promising avenue for preclinical evaluation of cell and gene therapies. Targeting of the subretinal fluid compartment (bleb) is critical to the procedure, especially if treatment of the cone-rich area centralis is required (i.e.
View Article and Find Full Text PDFObjectives: To analyse the incidence of persistence and recurrence after the peeling of idiopathic epiretinal membrane (ERM) and to describe its clinical features.
Methods: This retrospective study included 666 eyes (645 patients) that underwent macular surgery for ERM removal. Optical coherence tomographic (OCT) images taken within three months after surgery and at the following visits, clinical parameters and surgery related factors were analysed to investigate the incidence and associated factors of ERM persistence and recurrence.
Background: The increasing congestion in emergency departments of all specialties is one of the most pressing challenges of our time.
Objective: The aim of this study is to make a well-founded contribution to the development of emergency case numbers in the tertiary sector (specialist clinics) of German ophthalmology. From this, the need to develop new control and triage mechanisms for ophthalmology can be derived.
Objective: Progressive retinal atrophy has been described after subretinal gene therapy utilizing the adeno-associated virus (AAV) vector platform. To elucidate whether this atrophy is a consequence of inherent properties of AAV, or if it is related to the surgical trauma of subretinal delivery, we analyzed data from an Investigational New Drug-enabling study for PDE6A gene therapy in nonhuman primates.
Design: Animal study (nonhuman primates), retrospective data analysis.
Article Synopsis
- The study aimed to compare the retention rates of two AAV gene therapy agents in different subretinal injection systems.
- Four subretinal cannulas from two manufacturers were tested, measuring retention using a standardized qPCR method.
- Results showed that all tested instruments had similar retention rates for both AAV serotypes, indicating they are equally effective for gene therapy applications.