Bridging the gap between omics research and dental practice.

Aim: The burgeoning field of omics research has witnessed exponential growth in both medicine and dentistry. However, despite more than a decade of advancements, clinical dentistry, particularly in Low- and Middle-Income Countries (LMICs), has seen limited progress in integrating omics-based approaches into routine practice. This review aims to provide a comprehensive overview of the integration of omics approaches in dentistry, focusing on the challenges and opportunities for translating research findings into clinical practice.

Case report: Enamel renal syndrome: a case series from sub-Saharan Africa.

Enamel Renal Syndrome (ERS) (OMIM # 204690) is a rare genetic condition characterised by hypoplastic amelogenesis imperfecta, failed tooth eruption, intra-pulpal calcifications, gingival enlargement and occasionally nephrocalcinosis. In this case series, we report on four unrelated patients with a confirmed molecular diagnosis of ERS ( pathogenic variants) from Sub-Saharan Africa. The pathognomonic oral profile of ERS was mostly fulfilled in these patients, with the notable addition of an odontoma in one patient.

The genetic determinants of oral diseases in Africa: The gaps should be filled.

are a major health concern and are the most prevalent . This problem is becoming more prominent in the rapidly growing populations of Africa. It is well documented that Africa exhibits the most diverse genetic make-up in the world.

Craniofacial, dental, and molecular features of Pyle disease in a South African child.

Introduction: Pyle Disease (PD), or familial metaphyseal dysplasia [OMIM 265900], is a rare autosomal recessive condition leading to widened metaphyses of long bones and cortical bone thinning and genu valgum. We detail the oro-dental and molecular findings in a South African patient with PD.

Methods: The patient underwent clinical, radiographic and molecular examinations.

Managing vertical dimensions in patients with Amelogenesis Imperfecta: A case report.

Amelogenesis imperfecta (AI) is a heterogeneous group of conditions characterized by inherited developmental defects of enamel. Patients with AI often have progressive and severe loss of occlusal vertical dimensions (OVD), resulting in challenging dental rehabilitation. In this case report, we present the management of a 24-year-old male patient who previously underwent orthodontics, direct and indirect restorations, and continued to have progressive tooth wear.