Publications by authors named "I A Myles"
Objective: Herein, we aimed to summarize the evidence-base for these interventions with a focus on the role of specific chemicals in driving AD.
Methods: A narrative review of nonprescription mitigation strategies in AD was conducted.
Results: We identified avoidance strategies for the various routes of exposure such as air pollution, water contamination, or inclusion in home goods, skin care products, and cleansers.
Article Synopsis
- MRSA infections pose a significant public health challenge, prompting the need for new treatment strategies beyond conventional antibiotics.
- The study explored the effects of TRP ion channel inhibitors on MRSA skin infections in mice, finding that blocking TRPA1 reduced infection severity, while TRPV1 deletion had no significant impact.
- The research revealed that inhibiting TRPA1 influenced protein expressions and metabolic pathways related to inflammation and immune response, suggesting TRPA1 antagonism could be an effective, low-cost treatment option for MRSA.
Response to Griffith: Antiracism in Basic Research on Racial Disparities.
Public Health Rep
August 2024
The clinical, mechanistic, and social impacts of air pollution on atopic dermatitis.
J Allergy Clin Immunol
October 2024
Atopic dermatitis (AD) is a complex disease characterized by dry, pruritic skin and significant atopic and psychological sequelae. Although AD has always been viewed as multifactorial, early research was dominated by overlapping genetic determinist views of either innate barrier defects leading to inflammation or innate inflammation eroding skin barrier function. Since 1970, however, the incidence of AD in the United States has increased at a pace that far exceeds genetic drift, thus suggesting a modern, environmental etiology.
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