Bone Marrow Involvement in Melanoma. Potentials for Detection of Disseminated Tumor Cells and Characterization of Their Subsets by Flow Cytometry.

Disseminated tumor cells (DTCs) are studied as a prognostic factor in many non-hematopoietic tumors. Melanoma is one of the most aggressive tumors. Forty percent of melanoma patients develop distant metastases at five or more years after curative surgery, and frequent manifestations of melanoma without an identified primary lesion may reflect the tendency of melanoma cells to spread from indolent sites such as bone marrow (BM).

First Report of from Russia.

A population of the criconematid species, identified as (Micoletzky, 1925), is reported from a natural habitat in northwestern Russia. Measurements and morpho-anatomy obtained with light microscopy and molecular characterization of this population are included in this paper. A population of the criconematid species, identified as (Micoletzky, 1925), is reported from a natural habitat in northwestern Russia.

[Characteristics of monoclonal antibodies to RS virus in immunoenzyme and immunofluorescence techniques].

According to the competitive ELISA test data, new preparations of monoclonal antibodies (MAb) to respiratory syncytial virus (RSV) differed in their blocking activity and they were directed to 3 different virus epitopes. MAb 9C5 and MAb 131-2A (CDC, Atlanta) competed against each other strongly and they were directed to epitope F1a of RSV F-protein. MAbs 8C5 and 10D8 showed a two-way blocking and were presumably topologically linked.

[Correlations of the antigenic specificity of human blood with the levels of antihemagglutinins to influenza viruses].

The results of the observations show that after active circulation of influenza A (H1N1), A (H3N2), and B viruses the degree of immune response (a rise in antihemagglutinin titres to the causative agent of an epidemic) differed significantly in subjects with different blood groups of the ABO(H) system. After active circulation of influenza A(H1N1) and A(H3N2) viruses, rises in the antibody titres to the etiological factor of the epidemic was more marked in subjects with blood groups O and A than in those with blood group B. After an influenza A(H3N2) epidemic a rise in the titres to this virus in subjects with blood group B occurred a season later and did not reach those high levels observed in subjects with blood groups O and A.