Publications by authors named "I A Lobach"
Secukinumab efficacy in patients with hidradenitis suppurativa assessed by the International Hidradenitis Suppurativa Severity Score System (IHS4): A post hoc analysis of the SUNSHINE and SUNRISE trials.
J Eur Acad Dermatol Venereol
October 2024
Introduction: The International Hidradenitis Suppurativa Severity Score System (IHS4) is a validated tool that measures inflammatory lesions, including draining tunnels, in hidradenitis suppurativa (HS).
Objective: To evaluate secukinumab efficacy using IHS4 in patients with moderate to severe HS.
Methods: Data from the SUNSHINE and SUNRISE trials, which assessed subcutaneous secukinumab 300 mg every 2 (SECQ2W) and 4 (SECQ4W) weeks in adults with moderate to severe HS, were analyzed.
In this review, we summarize the latest advances in the design of optical frequency-domain reflectometers (OFDRs), digital signal processing, and sensors based on special optical fibers. We discuss state-of-the-art approaches to improving metrological characteristics, such as spatial resolution, SNR, dynamic range, and the accuracy of determining back reflection coefficients. We also analyze the latest achievements in the OFDR-based sensors: the accuracy of spatial localization of the impact, the error in detecting temperatures, deformation, and other quantities, and the features of separate measurement of various physical quantities.
View Article and Find Full Text PDFArticle Synopsis
- Hidradenitis suppurativa (HS) is a chronic skin condition, and secukinumab has shown sustained effectiveness and good safety for treating moderate-to-severe HS, though its performance in previously treated patients is unclear.
- The study analyzes data from two phase III trials (SUNSHINE and SUNRISE) to assess how prior exposure to biologics influences the efficacy and safety of secukinumab in HS patients.
- Results showed that secukinumab was more effective than placebo at 16 weeks for both biologic-experienced and biologic-naïve patients, indicating it remains a viable treatment option regardless of prior biologic treatment.
This Letter presents the first demonstration, to our knowledge, of a Brillouin optical time domain analysis (BOTDA) system based on a self-sweeping fiber laser. The unique feature of such laser sources is the generation of a narrowband tunable radiation with a small (6 MHz) tuning step and a reasonably large tuning range (3 GHz) making self-sweeping lasers extremely attractive for use in BOTDA systems. Since the wavelength tuning occurs solely due to internal processes occurring in the laser cavity, there is no need to use complex current/temperature control and feedback systems.
View Article and Find Full Text PDFInternational Hidradenitis Suppurativa Severity Scoring System (IHS4) as a holistic measure of hidradenitis suppurativa disease severity compared with Hurley staging: A post hoc analysis of the SUNRISE and SUNSHINE phase 3 trials of secukinumab.
J Eur Acad Dermatol Venereol
June 2024