Publications by authors named "I A Kraft"
Purpose: To identify likely germline DNA variants from sequential tumor profiling data from hematopoietic malignancies (HMs).
Methods: The coefficient of variance was calculated from variant allele frequency of next-generation sequencing assays. Variants' likelihood of being germline was ranked on a 1 to 5 scale.
Article Synopsis
- Anorexia nervosa (AN) is a serious eating disorder marked by extreme weight loss and an inability to recognize the severity of low body weight, often accompanied by inflammation and altered blood markers.
- The study analyzed specific chemokine receptors (CCR4, CCR6, CXCR3, and CXCR4) in T cells of female adolescents with AN, noting increased levels before treatment and changes after 6 weeks of therapy.
- Key findings indicate that CXCR4 expression correlates with mental health issues and serves as a predictor for body mass index and fat mass index, highlighting its potential role in AN's development.
Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood.
View Article and Find Full Text PDFIdentifying potential germline variants from sequencing hematopoietic malignancies.
Hematology Am Soc Hematol Educ Program
December 2020
Next-generation sequencing (NGS) of bone marrow and peripheral blood increasingly guides clinical care in hematological malignancies. NGS data may help to identify single nucleotide variants, insertions/deletions, copy number variations, and translocations at a single time point, and repeated NGS testing allows tracking of dynamic changes in variants during the course of a patient's disease. Tumor cells used for NGS may contain germline, somatic, and clonal hematopoietic DNA alterations, and distinguishing the etiology of a variant may be challenging.
View Article and Find Full Text PDFNext-generation sequencing (NGS) of bone marrow and peripheral blood increasingly guides clinical care in hematological malignancies. NGS data may help to identify single nucleotide variants, insertions/deletions, copy number variations, and translocations at a single time point, and repeated NGS testing allows tracking of dynamic changes in variants during the course of a patient's disease. Tumor cells used for NGS may contain germline, somatic, and clonal hematopoietic DNA alterations, and distinguishing the etiology of a variant may be challenging.
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