Effects of Quercetin against fluoride-induced neurotoxicity in the medial prefrontal cortex of rats: A stereological, histochemical and behavioral study.

Background: Exposure to high levels of fluoride leads to brain developmental and functional damage. Motor performance deficits, learning and memory dysfunctions are related to fluoride neurotoxicity in human and rodent studies.

Materials And Methods: Here, we evaluated the effects of Quercetin treatment (25 mg/kg) against sodium fluoride-induced neurotoxicity (NaF, 200 ppm) in the medial prefrontal cortex (mPFC) of male adult rats based on oxidative markers, behavioral performances, mRNA expressions, and stereological parameters.

Microglia/macrophage polarization regulates spontaneous remyelination in intermittent cuprizone model of demyelination.

Central nervous system (CNS) lesions can repeatedly be de-and remyelinated during demyelinating diseases such as multiple sclerosis (MS). Here, we designed an intermittent demyelination model by 0.3 % Cuprizone feeding in C57/BL6 mice followed by two weeks recovery.

Quercetin as a possible complementary therapy in multiple sclerosis: Anti-oxidative, anti-inflammatory and remyelination potential properties.

Multiple sclerosis (MS) is a complex autoimmune disorder of the central nervous system (CNS) which causes various symptoms such as fatigue, dyscoordination weakness and visual weakness. The intricacy of the immune system and obscure etiology are the main reasons for the lack of a definite treatment for MS. Oxidative stress is one of the most important key factors in MS pathogenesis.