Cisterna magna arachnoid membrane suturing decreases incidence of pseudomeningocele formation and incisional CSF leakage.

Objective: A pseudomeningocele and an incisional cerebrospinal fluid leak are considered frequent complications following neurosurgical operations. The rate of these complications especially increases following neurosurgical procedures on the posterior cranial fossae. According to some publications, the rate of pseudomeningoceles has been reported as high as 40%, whereas that of incisional cerebrospinal fluid leaks is up to 17%.

Review of surgical treatment of insular gliomas: challenges and opportunities.

Intracerebral tumors of the insular lobe are quite frequent, however treatment of patients with this pathology still remains a challenging and controversial issue of neurosurgery. First of all, this is associated with the localization of tumors in the area of eloquent anatomical structures: M1--M2 segment of the middle cerebral artery, lenticulostriate arteries, basal ganglia, and internal capsule, which causes a high rate of postoperative complications in these patients. Most insular tumors are amenable for resection with a reasonable rate of postoperative complications, although most of the surgery-related complications resulting in substantial deficits are due to lesions of eloquent anatomical structures located in this compact anatomical space.

A novel device for hands-free positioning and adjustment of the surgical microscope.

The authors have developed a novel device, which they have named Mari, that allows hands-free utilization of the surgical microscope. The device is attached to the eyepieces of a multifunction counterweight-balanced surgical microscope and consists of a metallic holder with supportive plates that facilitate interaction between the device and surgeon's head. On the holder are installed 1) an electric switch, which allows the surgeon to release the microscope's magnetic clutches, allowing movement of the microscope along the x, y, and z axes as well as the rotational and diagonal ones, and 2) a joystick at the level of the surgeon's mouth for adjustment of focus and zoom.

Cancer-associated immune-mediated syndromes: Pathogenic values and clinical implementation.

The ability of tumors to provoke formation of cancer-associated secondary immunodeficiency (CASID) with predominant suppression of CMI and cancer-associated secondary immunodeficiency with clinical autoimmunity syndrome (CASICAS) with triggering of a set of the autoimmune deviations is appearing to be a key event in the restriction of hosts' anti-tumor immunity. Earlier the existence of the above-mentioned syndromes was demonstrated in BCC and GBM patients. In order to reach a point where immunological phenotypes in GBM and BCC can be clarified clinically and, partly, pathogenically, we have conducted a series of studies of typical and atypical types of immune responsiveness in patients with GBM and BCC.

[Glial tumors of the brain: current aspects of the immunopathogenesis and immunogenodiagnosis].

Glioblastoma growth is a genetically regulated process. Loss or inactivation of genes - tumor suppressors may give rise to tumors and their progression. Glioblastoma multiforme is followed by a number of genetic breakages.