Publications by authors named "I A Janssens"
As global fertilizer application rates increase, high-quality datasets are paramount for comprehensive analyses to support informed decision-making and policy formulation in crucial areas such as food security or climate change. This study aims to fill existing data gaps by employing two machine learning models, eXtreme Gradient Boosting and HistGradientBoosting algorithms to produce precise country-level predictions of nitrogen (N), phosphorus pentoxide (PO), and potassium oxide (KO) application rates. Subsequently, we created a comprehensive dataset of 5-arcmin resolution maps depicting the application rates of each fertilizer for 13 major crop groups from 1961 to 2019.
View Article and Find Full Text PDFGenetic engineering of regulatory T cells (Tregs) presents a promising avenue for advancing immunotherapeutic strategies, particularly in autoimmune diseases and transplantation. This study explores the modification of Tregs via mRNA electroporation, investigating the influence of T-cell activation status on transfection efficiency, phenotype, and functionality. For this CD45RA Tregs were isolated, expanded, and modified to overexpress brain-derived neurotrophic factor (BDNF).
View Article and Find Full Text PDFClimate change has altered the timing of recurring biological cycles in both plants and animals. Phenological changes may be unequal within and among trophic levels, potentially impacting the intricate interactions that regulate ecosystem functioning. Here we compile and analyse a global dataset of terrestrial phenological observations, including nearly half a million time series for both plants and animals.
View Article and Find Full Text PDFArticle Synopsis
- * Conducted in Belgium, the research involved 191 participants over two months, showing significant reductions in blood glucose levels for those with T2DM and prediabetes.
- * Results indicated a 27.9% reduction in glycemia for T2DM participants and a 4.7% reduction for prediabetic participants, while those with normal blood sugar levels showed no significant changes.
Article Synopsis
- The vitamin D receptor (VDR) is essential for regulating bone health, and its activation typically involves binding to vitamin D and the recruitment of coactivators for gene transcription.
- This study used mice with a deletion of the VDR-AF2 domain to explore how VDR functions without coactivators, revealing that these mutant mice had significant bone issues compared to regular knockout mice.
- Findings indicated that while a rescue diet could improve some bone problems in one group of mutant mice, coactivator-independent VDR functions likely play a more vital role in organs other than bones, affecting overall mineral homeostasis.