Pharmacometabonomics, pharmacogenomics and personalized medicine.

The development of genomics in the last decade opened new perspectives to fulfill the permanent ideal of therapy, namely personalization of therapy (of medicine) by using of adage: "the right drug to the right patient". The pharmacogenomics, developed in these 10 years, already permitted the identification of the patients with side drug effects risk by detection of the presence of single nucleotide polymorphisms (SNPs) from enzymatic systems implied in drugs metabolism such as CYP450. More recently, the emergence of pharmacometabonomics permitted the appreciation of the influence of the metabolic factors (and of the environment) on the genes expression.

Feasibility study of substitution hormonal therapy on cardiovascular diseases in post-menopausal women (part II).

Background: In a finished feasibility study concerning the effects of substitution hormonal therapy (SHT) on the cardiovascular status in the post-menopausal women (pmw) we analysed the rate of participation of the Romanian women, the reasons for abandon to participation, etc. in a multicentric international study.

Objectives: This study had intention to analyse the cardiovascular status of the pmw proposed for STH.

Diagonal earlobe crease: a coronary risk factor, a genetic marker of coronary heart disease, or a mere wrinkle. Ancient Greco-Roman evidence.

In a new study on the relationship between the diagonal earlobe crease (DELC), first described by Frank in 1973, and the presence of chronic ischemic heart disease, four main hypotheses are presented. Hypothesis 1: DELC is a coronary risk factor or a marker of coronary risk factor. Hypothesis 2: DELC is a genetic marker of atherosclerotic coronary disease.

Ventricular late potentials. Part II. Clinical importance and interpretation.

This second part of a review on the ventricular late potentials (VLP) includes most of the latest data on their clinical interpretation. A description of VLP characteristics in normal subjects is followed by an analysis of their significance in several cardiovascular diseases in which VLP presence has been almost currently investigated, i.e.

Ventricular late potentials. Part I. Techniques, detection, interpretation.

The first part of this review on the ventricular late potentials (VLP) presents the actual methods of diagnosis by: 1. Analysis in the time domain (ATD), currently used in most of the studies on the VLP. 2.