[The influence of the actoprotectors on lipid peroxidation and erythrocyte membranes in rats poisoned with malathion ].

Actoprotecting properties ofbemitil, tietasol in combination with atropin were studied in red cell membranes and lipid peroxidation of rats poisoned with MI in a dose 320 mg/kg (0.9 LD50). Atropin treatment showed a low effect.

[Effect of sugar-reducing therapy on renal function in patients with type II diabetes mellitus].

Renal function was examined in 66 proteinura-free patients at the age of 40-67 years having diabetes mellitus (DM) type II for 4-10 years and HbA1c 7% maximum. Non-insulin-dependent DM was found to affect both glomerular and tubulointerstitial renal systems. This was indicated by reduced glomerular filtration, microalbuminuria, hyperenzymuria, high blood and urine levels of beta-2-microglobulin.

[Characteristics of enzymatic function of the stomach in gastroduodenal diseases in children with regard to gastric carcinogenesis].

The paper deals with a description of the biochemical properties of the isoforms of pepsinogen pepsin of gastric mucosa and blood serum in children suffering from duodenal ulcerative disease as well as in atrophic and subtrophic lesions of gastric mucosa. Atrophic gastritis was found to involve an inhibited biosynthesis of the Ist fraction of pepsinogen while ulcerative-erosive lesions of the gastro-duodenal area--an increased level of the 3rd isoform of pepsinogen.

[Prospects for designing medicines based on carnosine (several new applications)].

The perspectives in application of carnosine, its analogs (histidine-containing dipeptides), and their derivatives as components of medicinal drugs are reviewed. These applications are based on antioxidative properties of carnosine and its analogs, their chelating activity towards transient valency metals as well as on their specific neurotransmitter functions in the brain. Combination of carnosine with other antioxidants and the use of copper or zinc complexes with histidine-containing dipeptides are considered as perspective trends in the design of new drugs.