Functional asymmetry of the cerebral hemispheres: its role in the pathogenesis of ectromelia and melanoma in (CBAxC57BL/6)F1 mice.

The aim of the present work was to identify the role of functional asymmetry in the cerebral hemispheres in the pathogenesis of infectious and oncological pathology in (CBAxC57BL/6)F1 mice. Mice with lefthemisphere dominance of motor functions ("right-handers") were found to be more resistant to infection with ectromelia virus and to show slower growth of tumors after subcutaneous injection of B-16 melanoma than animals with right-hemisphere dominance of motor control ("left-handers"). Thus, this report provides the first evidence for the role of functional asymmetry of the nervous system in the pathogenesis of ectromelia and melanoma (B-16) in (CBAxC57BL/6)F1 mice.

[Functional asymmetry of the brain hemispheres: the role in pathogenesis of ectromelia and melanoma in (CBAxC57BL/6)F1 mice].

The object of the research was to identify role of functional nervous asymmetry in formation of pathology in experimental animals. The role of functional asymmetry of the brain hemispheres in development of ectromelia and melanoma at (CBAxC57BL/6)F1 mice was investigated. It has been established, that mice with domination of motor functions in the left hemisphere ("right-handed") are more resistant against infection with ectromelia virus, and melanoma B-16 grows more slowly in these mice as compated with animals with domination of motor functions of the right hemisphere ("left-handed").

The role of asymmetry of nervous and immune systems in the formation of cellular immunity of (CBaxC57Bl/6) F1 mice.

We have previously shown the existence of functional asymmetry of the immune system and the role of brain hemispheres and different lobes of thymus in the development of humoral immune response in (CBA x C57Bl/6) F1 mice. The role of asymmetry of the nervous and immune systems in the formation of the cellular immune response [delayed-type hypersensitivity (DTH) reaction] in these mice has been studied in our work. In order to test the influence of asymmetry of the primary immune organs, thymus, on the cellular immune response, mice were thymectomized and then we studied the effect of the injection of cells from contralateral thymus lobes of right-dominant and left-dominant donors by motor asymmetry on how pronounced the DTH reaction in the back left paw was.

Asymmetry of delayed type hypersensitivity reaction in mice.

The intensity of delayed type hypersensitivity reactions in the left and right paws was studied in mice divided into left- and right-pawed by the motor asymmetry of the brain. The reaction was more pronounced in the left paw in all animals irrespective of motor asymmetry. Motor asymmetry of the brain hemispheres little contributed to the manifestation of differences in the delayed type hypersensitivity reactions in the left and right paws.

The Interdependence of Behavior and Immunity: Possible Mechanisms and Significance.

Mechanisms and significance of interdependence of immunity and behavior are very important line of investigations. The aim of this work was to present an analytical survey of own and literature data accumulated worldwide on this problems. The continuation of such investigations will favor not only to the accumulation of fundamental data in this field, but to application of the results obtained for immuno- and psychoregulation as well.