[Scientific approaches to development of medicinal formulation based on biotechnological substance].

The study demonstrated possible design of a medicinal formulation in the form of suppositories comprising human recombinant interferon-alpha2 and dry aloe extract. The approaches to the development of the suppositories were technology-derived. No interaction between the active and auxiliary components was proved by solid state 1H-NMR spectroscopy.

[Preclinical investigation and standardization of metronidazole soft dosage forms].

Comparative acute and subacute toxicity of Dentamet gel and Metrovagin suppositories manufactured by ZAO Altaivitaminy was studied with using analogous drugs, i. e. Metrogil Denta, a gel for the gingivae, manufactured by Unique Pharmaceutical Laboratories (India), and Flagil manufactured by Haupt Farma Livron (France) as the reference drugs.

[Bisphosphonates in pharmacotherapy of bone diseases].

Bisphosphonates represent a new class of drugs that has been developed in the past three decades for the treatment of various bone diseases and calcium metabolism disorders. Possessing high affinity to the bone-forming minerals, these substances can be used as inhibitors of the ectopic calcification and bone resorption. Bisphosphonates not only prevent from the loss of bones in the case of osteoporosis of various types (e.