Publications by authors named "I A Dudar'"
Article Synopsis
- The study aimed to evaluate the impact of the calcimimetic Etelcalcetide on secondary hyperparathyroidism in end-stage renal disease patients undergoing hemodialysis, comparing its effects to those in patients not treated with calcimimetics.
- A total of 203 patients were included, with 71 receiving Etelcalcetide and 132 in a historical control group, and results measured included changes in serum levels of parathyroid hormone, calcium, and phosphorus over 12 months, focusing on mortality and cardiovascular events.
- Results showed significant decreases in parathyroid hormone levels and cardiovascular event rates in the Etelcalcetide group compared to the historical group, suggesting a notable benefit of the treatment in reducing complications associated
The article summarises data on the activity of tubular enzymes having marked organ-specific characteristics related to kidneys. They are N-acetyl-beta-D-glucosaminidase (NAG), its thermostable isoenzyme NAG B and beta-galactosidase localised in lysosomes. L-canavinine, ornithine aminotransferase having mitochondrial localization have also been discussed in the article.
View Article and Find Full Text PDFActivity of tubular lysosomic (N-acetyl-beta-D-glucosaminidase--NAG, its thermostable isoenzyme NAG B and B-galactosidase--beta-GAL) and mitochondrial (L-canavanine: ornithine amidinetransferase--COAT) enzymes were measured in urine of 30 patients with diabetes complicated by diabetic nephropathy (DN). It was shown that activity of NAG, especially its thermostable isoenzyme NAG B and also beta-GAL in urine of DN patients was higher compare to those in healthy subject. Moreover COAT activity was registered in urine of DN patients while it is not presented in healthy persons.
View Article and Find Full Text PDFThe clinical and laboratory investigation was done on 40 patients with kidney disfunction (glomerulonefritis), treated by standard medicines with regulary infrared total body heating (from 15-20 to 40 min) daily during 10 days. Control group of 37 patients, was treated only by standard medicines. The thermochambers construction forces the possibility of normal temperature air breathing under the radial skin heating to 50-60 degrees C.
View Article and Find Full Text PDFAbnormalities were studied of lipid metabolism in patients with glomerulonephritis (GN) depending on the presence of herpes infection (antibodies to herpes simplex virus and cytomegalovirus) versus similar indices in GN patients free from this infection (n = 75). Of these, 34 presented with the urinary syndrome (US), 41 had nephrotic syndrome (NS). Abnormalities of lipid metabolism in GN patients (irrespective of the syndrome) were shown to be more manifest in the presence of herpes infection.
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