[THE ACTUAL APPROACHES TO PROBLEM OF IMPORT SUBSTITUTION IN TH FIELD OF PRODUCTION GROWTH MEDIUM].

The import substitution becomes one of strategic tasks of Russian economy as a result of imposition of economic sanctions on part of the USA, EU countries, Japan and number of other states. The development of structure and technology of production of national import substituted growth mediums permits satisfying needs of laboratory service of Russia inactive storage and to secure appropriate response to occurring challenges and new biological menaces and support bio-security of state at proper level. The presented data concerning substantiation of nomenclature of growth mediums and transport system permit satisfying in fullness the needs of clinical and sanitary microbiology in growth mediums of national production and to give up of import deliveries without decreasing of quality of microbiological studies.

[Designing of laboratories is crucial for the management of biorisks in the work with pathogenic biological agents].

Currently in the Russian Federation there is planned the reconstruction and construction of new facilities tailored for the work with pathogenic biological agents of I-II pathogenicity groups, with bearing in mind the modern level of the development of equipment and technologies technological. However, in Russia there is no specialized institutions for the designing of such facilities. There were developed "Guidelines for the designing of objects of the Medical Sanitary Unit No164, tailored for the work with pathogenic biological agents of I-II pathogenicity groups", in which there were taken into account the requirements of modern Russian regulations in the field of biosafety air purification, fire safety.

[Biosafety in the study of samples of extraterrestrial origin by an example of preparation for the "Phobos-Grunt" mission].

The necessity of microbial studying the soil from Phobos and terrestrial biological objects, which were for a long time in deep space and may represent a biological hazard has been shown. Developed medical and technical requirements for laboratories comply with Russian regulations and recommendations of international instruments for the ensuring of biosafety on the basis of process (continuous) biorisk management.

[Perspectives of creation of vaccines against tick bite for nonspecific prophylaxis of vector borne diseases].

Prophylaxis of infectious diseases transferred by ticks is an important problem of contemporary medicine. One of the perspective approaches to solve this problem is the creation of vaccines against tickbite (anti-tickvaccines). Contemporary methods of the control of infectious diseases transferred by ticks are described in the review.