Multifaceted role of the actin-binding protein WIP: Promotor and inhibitor of tumor progression and dissemination.

Cancer cells depend on actin cytoskeleton reorganization to achieve hallmark malignant functions including abnormal activation, proliferation, migration and invasiveness. (Neural)-Wiskott-Aldrich Syndrome protein ((N-)WASP) binds actin and forms a complex with the WASP-interacting protein (WIP), which plays a critical role in regulating the actin cytoskeleton, through (N)-WASP-dependent and independent functions. Mutations in the WIP gene (WIPF1) lead to severe early onset immunodeficiency in humans and severe autoimmunity and shortened lifespan in mice.

On the optimization of the interconnection of photovoltaic modules integrated in vehicles.

The design of photovoltaic modules for vehicle-integrated photovoltaics (VIPVs) must consider specific operating conditions like partial shading. Module cell interconnection topology must demonstrate resilience to such conditions to maximize energy generation without compromising shadow-free performance, manufacturing complexity, or cost. This study presents a modeling tool for VIPV, calculating effective irradiance on the VIPV surface using Light Detection And Ranging (LiDAR) point clouds to estimate the direct component and sky images for the diffuse irradiance.

Challenges and Opportunities in Calibrating Low-Cost Environmental Sensors.

The use of low-cost environmental sensors has gained significant attention due to their affordability and potential to intensify environmental monitoring networks. These sensors enable real-time monitoring of various environmental parameters, which can help identify pollution hotspots and inform targeted mitigation strategies. Low-cost sensors also facilitate citizen science projects, providing more localized and granular data, and making environmental monitoring more accessible to communities.

Cell adhesion and migration in disease: translational and therapeutic opportunities.

In September 2023 members of the cell adhesion and cell migration research community came together to share their latest research and consider how our work might be translated for clinical practice. Alongside invited speakers, selected speakers and poster presentations, the meeting also included a round table discussion of how we might overcome the challenges associated with research translation. This meeting report seeks to highlight the key outcomes of that discussion and spark interest in the cell adhesions and cell migration research community to cross the perceived valley of death and translate our work into therapeutic benefit.