Translocated anterior mitral leaflet sparing is a viable treatment option for both degenerative and functional mitral valve disease.

Background: We present a technique for mitral valve (MV) replacement that preserves the anterior mitral leaflet (AML) using complete chordal-sparing mitral valve replacement (CCS-MVR), which maintains the architecture of the left ventricle. This technique is beneficial for patients with functional, degenerative, and infective MV disease who were unable to undergo MV repair. The objective of this study is to ascertain the most efficacious treatment for MV disease.

Novel Thiazolidinedione and Rhodanine Derivatives Regulate Glucose Metabolism, Improve Insulin Sensitivity, and Activate the Peroxisome Proliferator-Activated γ Receptor.

Sixteen novel thiazolidinedione (TZD) and rhodanine (RD) derivatives were designed and synthesized by introducing a pyrimidine moiety at different sites of pioglitazone's structure. The effects of synthesized compounds on regulating glucose metabolism, improving insulin sensitivity, and activating the peroxisome proliferator-activated γ receptor (PPAR-γ) were evaluated in βTC6 cells. Compounds TZDs # , , , and reduced the basal insulin secretion by ∼20.

Microalgae's polysaccharides, are they potent antioxidants? Critical review.

The scientific community continue to explore novel bioactive molecules by investigating natural origins; microalgae are photosynthetic organisms considered as a sustainable resource to use in many fields. They present a high diversity in species and richness in terms of attractive bio-compounds. The aim of this review is to (1) provide first an overview of current issues related to oxidative stress, and propose a natural metabolite derived from eukaryotic and prokaryotic microalgae; 'polysaccharides' as a powerful antioxidant agent, then, (2) organize the available data on the antioxidant potential of polysaccharides derived from the main microalgal groups (red microalgae, green microalgae, and cyanobacteria) and especially highlighted the key species of each group (Porphyridium sp.

Status Report of Renal Transplant Patients in Niger.

Background: Kidney transplantation is the treatment of choice for end-stage chronic kidney disease. It improves quality of life and increases life expectancy. At present, Niger is one of the poorest countries in the world does not practice kidney transplantation; thus, patients continue to be referred to other countries for transplantation.