Appl Microbiol Biotechnol
September 2024
The fecal microbiome is identical to the gut microbial communities and provides an easy access to the gut microbiome. Therefore, fecal microbial transplantation (FMT) strategies have been used to alter dysbiotic gut microbiomes with healthy fecal microbiota, successfully alleviating various metabolic disorders, such as obesity, type 2 diabetes, and inflammatory bowel disease (IBD). However, the success of FMT treatment is donor-dependent and variations in gut microbes cannot be avoided.
View Article and Find Full Text PDFAlthough countless gut microbiome studies on colitis using mouse models have been carried out, experiments with small sample sizes have encountered reproducibility limitations because of batch effects and statistical errors. In this study, dextran-sodium-sulfate-induced microbial dysbiosis index (DiMDI) was introduced as a reliable dysbiosis index that can be used to assess the state of microbial dysbiosis in DSS-induced mouse models. Meta-analysis of 189 datasets from 11 independent studies was performed to construct the DiMDI.
View Article and Find Full Text PDFAn intermittent fasting regimen is widely perceived to lead to various beneficial health effects, including weight loss, the alleviation of insulin resistance, and the restructuring of a healthy gut microbiome. Because it shares certain commonalities with this dietary intervention, Ramadan fasting is sometimes misinterpreted as intermittent fasting, even though there are clear distinctions between these two regimens. The main purpose of this study is to verify whether Ramadan fasting drives the same beneficial effects as intermittent fasting by monitoring alterations in the gut microbiota.
View Article and Find Full Text PDFGut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological importance than the other major SCFAs (acetate and propionate). Most butyrate producers belong to the Clostridium cluster of the phylum Firmicutes, such as , , , , , , and . They metabolize carbohydrates the butyryl-CoA: acetate CoA-transferase pathway and butyrate kinase terminal enzymes to produce most of butyrate.
View Article and Find Full Text PDFFinger millet () is a staple food in several parts of the world because of its high nutritional value. In addition to its high nutrient content, finger millet contains numerous bioactive compounds, including polyphenol (10.2 mg/g TAE), flavonoid (5.
View Article and Find Full Text PDFDietary studies play a crucial role in determining the health-benefiting effects of most food substances, including prebiotics, probiotics, functional foods, and bioactive compounds. Such studies involve gastrointestinal digestion and colonic fermentation of dietary substances. In colonic fermentation, any digested food is further metabolized in the gut by the residing colonic microbiota, causing a shift in the gut microenvironment and production of various metabolites, such as short-chain fatty acids.
View Article and Find Full Text PDFColorimetric sensing, which provides effective detection of bio-molecular signals with one's naked eye, is an exceptionally promising sensing technique in that it enables convenient detection and simplification of entire sensing system. Though colorimetric sensors based on all-dielectric nanostructures have potential to exhibit distinct color variations enabling manageable detection due to their trivial intrinsic loss, there is crucial limitation that the sensitivity to environmental changes lags behind their plasmonic counterparts because of relatively small region of near field-analyte interaction of the dielectric Mie-type resonator. To overcome this challenge, we proposed all-dielectric metasurface colorimetric sensor which exhibits dual-resonance in the visible region.
View Article and Find Full Text PDFMetasurface color filters (MCFs) have attracted considerable attention thanks to their compactness and functionality as a candidate of an optical element in a miniaturized image sensor. However, conventional dielectric and plasmonic MCFs that have focused on color purity and efficiency cannot avoid reflection in principle, which degrades image quality by optical flare. Here, we introduce absorptive-type MCFs through truncated-cone hyperbolic metamaterial absorbers.
View Article and Find Full Text PDFEnvironmental factors can influence the composition of gut microbiota, but understanding the combined effect of lifestyle factors on adult gut microbiota is limited. Here, we investigated whether changes in the modifiable lifestyle factors, such as cigarette smoking, alcohol consumption, sleep duration, physical exercise, and body mass index affected the gut microbiota of Korean navy trainees. The navy trainees were instructed to stop smoking and alcohol consumption and follow a sleep schedule and physical exercise regime for eight weeks.
View Article and Find Full Text PDFIEEE Trans Biomed Circuits Syst
October 2019
Internet-of-things applications that use machine-learning algorithms have increased the demand for application-specific energy-efficient hardware that can perform both learning and inference tasks to adapt to endpoint users or environmental changes. This paper presents a multilayer-learning neuromorphic system with analog-based multiplier-accumulator (MAC), which can learn training data by stochastic gradient descent algorithm. As a component of the proposed system, a current-mode MAC processor, fabricated in 28-nm CMOS technology, performs both forward and backward processing in a crossbar structure of 500 × 500 6-b transposable SRAM arrays.
View Article and Find Full Text PDFIEEE Trans Biomed Circuits Syst
February 2018
This paper presents an IC implementation of on-chip learning neuromorphic autoencoder unit in a form of rate-based spiking neural network. With a current-mode signaling scheme embedded in a 500 × 500 6b SRAM-based memory, the proposed architecture achieves simultaneous processing of multiplications and accumulations. In addition, a transposable memory read for both forward and backward propagations and a virtual lookup table are also proposed to perform an unsupervised learning of restricted Boltzmann machine.
View Article and Find Full Text PDFBackground: Although Clostridium perfringens has been reported as a cause of antibiotic-associated diarrhea (AAD), it is uncommon to detect this pathogen in clinical microbiology laboratories in Korea. The aim of this study was to investigate the prevalence of C. perfringens toxin in patients suspected of having AAD.
View Article and Find Full Text PDFIEEE Trans Biomed Circuits Syst
June 2017
This paper presents an amplifier-less and digital-intensive current-to-digital converter for ion-sensitive FET sensors. Capacitance on the input node is utilized as a residue accumulator, and a clocked comparator is followed for quantization. Without any continuous-time feedback circuit, the converter performs a first-order noise shaping of the quantization error.
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