Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models.

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder characterized by joint destruction due to synovial hypertrophy and the infiltration of inflammatory cells. Despite substantial progress in RA treatment, challenges persist, including suboptimal treatment responses and adverse effects associated with current therapies. This study investigates the anti-rheumatic capabilities of the newly identified multi-protein kinase inhibitor, KMU-11342, aiming to develop innovative agents targeting RA.

KMU-191 Induces Apoptosis in Human Clear Cell Renal Cell Carcinoma Caki Cells Through Modulation of Bcl-xL, Mcl-1 (L), c-FLIP (L), and p53 Proteins.

The anti-proliferative effects of a newly developed 3-acyl-5-aryl-3,5-diaminoindazole analog, KMU-191, have been previously evaluated in various cancer cells. However, the detailed anti-cancer molecular mechanisms of KMU-191 remain unknown. In this study, we investigated anti-cancer mechanisms by which KMU-191 regulates apoptosis-related genes in human clear cell renal cell carcinoma Caki cells.

Cyclin-Dependent Kinase Inhibitor BMI-1026 Induces Apoptosis by Downregulating Mcl-1 (L) and c-FLIP (L) and Inactivating p-Akt in Human Renal Carcinoma Cells.

Previous studies have investigated the inhibitory effect of BMI-1026 on cyclin-dependent kinase 1 in vitro. However, the molecular mechanisms by which BMI-1026 treatment leads to cancer cell death remain unclear. This study was conducted to investigate the anticancer mechanisms of BMI-1026 on human renal carcinoma Caki cells.

Spark Plasma Sintering Behavior of Nb-Mo-Si Alloy Powders Fabricated by Hydrogenation-Dehydrogenation Method.

In this study, the sintering behaviors of Nb-6Mo-20Si-3Cr (at percentage) in situ composite powders were studied. The Nb alloy powder was fabricated by a hydrogenation-dehydrogenation method, and both the alloy ingot and powders consisted of two phases: An Nb metal phase and the α-NbSi phase. Consolidation of the alloy powders was performed at 1500, 1600, and 1700 °C using spark plasma sintering, and the microstructures and phases formed at various sintering temperatures were analyzed.

Metabolome Profiling of Partial and Fully Reprogrammed Induced Pluripotent Stem Cells.

Acquisition of proper metabolomic fate is required to convert somatic cells toward fully reprogrammed pluripotent stem cells. The majority of induced pluripotent stem cells (iPSCs) are partially reprogrammed and have a transcriptome different from that of the pluripotent stem cells. The metabolomic profile and mitochondrial metabolic functions required to achieve full reprogramming of somatic cells to iPSC status have not yet been elucidated.

High Frequency Induction Heated Synthesis and Consolidation of Nanostructured TaSi2-WSi2 Composite.

A dense nanostructured TaSi2-WSi2 composite was simultaneously synthesized and sintered by the high frequency induction heating method within 2 minutes from mechanically activated powder of Ta, W and Si. A highly-dense TaSi2-WSi2 composite was produced under simultaneous application of a 80 MPa pressure and the induced current. The mechanical properties and microstructure were investigated.

Mechanochemical Synthesis and Rapid Consolidation of Nanostructured CoTi-Al2O3 Composite by Pulsed Current Activated Sintering and Its Mechanical Properties.

Nano-powders of CoTi and Al2O3 were synthesized from CoTiO3 and 2Al powders by high energy ball milling. Nanocrystalline Al2O3 reinforced composite was consolidated by pulsed current activated sintering within one minute from mechanochemically synthesized powders of CoTi and Al2O3. The relative density of the composite was 97%.