The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.

TAPL is a lysosomal ATP-binding cassette transporter that translocates a broad spectrum of polypeptides from the cytoplasm into the lysosomal lumen. Here we report that, in addition to its well-known role as a peptide translocator, TAPL exhibits an ATP-dependent phosphatidylserine floppase activity that is the possible cause of its high basal ATPase activity and of the lack of coupling between ATP hydrolysis and peptide efflux. We also present the cryo-EM structures of mouse TAPL complexed with (i) phospholipid, (ii) cholesteryl hemisuccinate (CHS) and 9-mer peptide, and (iii) ADP·BeF.

Electrochemical Reduction of CO to CO by N,S Dual-Doped Carbon Nanoweb Catalysts.

Converting CO into useful chemicals through an electrocatalytic process is an attractive solution to reduce CO in the atmosphere. However, the process suffers from high overpotential, low activity, or poor product selectivity. In this study, N,S dual-doped carbon nanoweb (NSCNW) materials were proposed as an efficient nonmetallic electrocatalyst for CO reduction.

An N-doped porous carbon network with a multidirectional structure as a highly efficient metal-free catalyst for the oxygen reduction reaction.

Metal-free catalysts have gained substantial attention as a promising candidate to replace the expensive platinum (Pt) catalysts for the oxygen reduction reaction (ORR) which is a key process in low temperature fuel cells. Development of highly efficient and mass-producible N-doped carbon catalysts, however, remains to be a great challenge. In this study, N-doped porous carbon (NPC) materials were synthesized via a simple, cost-effective and scalable method for mass production by using the d-gluconic acid sodium salt, pyrrole, Triton X-100 and KOH.

Honeycomb-Like Nitrogen-Doped Carbon 3D Nanoweb@Li S Cathode Material for Use in Lithium Sulfur Batteries.

Current lithium-ion batteries have a low theoretical capacity that is insufficient for use in emerging electric vehicles and energy-storage systems. The development of lithium-sulfur batteries utilizing Li S cathodes would be a promising option to overcome the capacity limitation. In this work, new three-dimensional (3D) honeycomb-like N-doped carbon nanowebs (HCNs) have been synthesized through a facile aqueous solution route for use as a cathode material in lithium-sulfur batteries.