Publications by authors named "Hyunsoo Yim"

Article Synopsis
  • The study investigates how the nervous system of nematodes changes during the dauer developmental stage, using advanced techniques like deep learning for chemical connectome reconstruction.
  • It finds that structural changes in neurons are closely linked to changes in connectivity, which influence specific behaviors such as nictation.
  • The analysis highlights significant rewiring of sensory neuron connections and increased clustering in motor neurons, suggesting the nematode's nervous system adapts to unfavorable conditions through a tailored connectome.
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Cilia are important for the interaction with environments and the proper function of tissues. While the basic structure of cilia is well conserved, ciliated cells have various functions. To understand the distinctive identities of ciliated cells, the identification of cell-specific proteins and its regulation is essential.

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Nictation is a behaviour in which a nematode stands on its tail and waves its head in three dimensions. This activity promotes dispersal of dauer larvae by allowing them to attach to other organisms and travel on them to a new niche. In this review, we describe our understanding of nictation, including its diversity in nematode species, how it is induced by environmental factors, and neurogenetic factors that regulate nictation.

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Tissue expansion techniques physically expand swellable gel-embedded biological specimens to overcome the resolution limit of light microscopy. As the benefits of expansion come at the expense of signal concentration, imaging volume and time, and mechanical integrity of the sample, the optimal expansion ratio may widely differ depending on the experiment. However, existing expansion methods offer only fixed expansion ratios that cannot be easily adjusted to balance the gain and loss associated with expansion.

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