Publications by authors named "Hyunjin Jo"

Herpes zoster (HZ), also known as shingles, is caused by the reactivation of latent varicella-zoster virus (VZV). Decreased VZV-specific T-cell immune responses significantly contribute to the development of HZ. Shingrix is a recombinant zoster vaccine that is currently used to prevent HZ.

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  • The study aimed to understand if brain changes in patients with isolated rapid eye movement sleep behavior disorder (iRBD) are progressive, distinct from normal aging, and linked to clinical symptoms.
  • Eighteen iRBD patients and 24 healthy controls underwent comprehensive assessments, including brain imaging, and findings revealed that iRBD patients had thinning cortices and caudate atrophy compared to controls, but none showed progression to Parkinson's disease during the follow-up.
  • Results indicate that while iRBD patients exhibit brain atrophy similar to early Parkinson's, this atrophy is slower than that seen with normal aging, and cognitive impairment does not show progression in these patients.
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Study Objectives: Obstructive sleep apnea (OSA) is a prevalent clinical problem significantly affecting cognitive functions. Surgical treatment is recommended for those unable to use continuous positive airway pressure. We aimed to investigate the therapeutic effect of upper airway surgery on the white matter (WM) microstructure and brain connectivity in patients with OSA.

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Objective: Lateral temporal lobe epilepsy (LTLE) has been diagnosed in only a small number of patients; therefore, its surgical outcome is not as well-known as that of mesial temporal lobe epilepsy. We aimed to evaluate the long-term (5 years) and short-term (2 years) surgical outcomes and identify possible prognostic factors in patients with LTLE.

Methods: This retrospective cohort study was conducted between January 1995 and December 2018 among patients who underwent resective surgery in a university-affiliated hospital.

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Eucheuma denticulatum is a red macroalgae with a high carbohydrate content. The fermentable sugars from E. denticulatum were obtained through sequential thermal acid hydrolysis, enzymatic saccharification, and detoxification.

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Globally, cyanobacteria frequently cause blooms that outcompete other species in the waterbody, affecting the diversity, decreasing water exchange rates, and promoting eutrophication that leads to excessive algal growth. Here, Dolichospermum circinale (akinetes) and Microcystic aeruginosa (resting cells), were isolated from the sediment in the Uiam Dam in the North Han River and near Ugok Bridge in the Nakdong River, respectively. The morphology, germination process and rates, and growth was evaluated in different environmental conditions.

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  • The study investigated changes in substructural volumes of the hippocampus and amygdala in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (TLE-HS).
  • It included 22 patients with left-sided TLE-HS and 26 with right-sided TLE-HS, comparing them to 28 healthy controls using advanced MRI techniques.
  • Findings revealed that volume reductions in hippocampus and amygdala substructures were dependent on the side of the seizure focus, with distinct patterns for left and right TLE-HS patients and correlations between clinical features and specific subregions.
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Purpose: To compare the characteristics of obstructive sleep apnea (OSA) between patients with epilepsy and patients without epilepsy and to investigate CPAP (Continuous Positive Airway Pressure) effect on seizures. Methods: Medical and polysomnography (PSG) data from 235 adult OSA patients with epilepsy (OE; 183 males; mean age, 49.8 years) and 268 age- and sex-matched OSA patients without epilepsy (OSE; 216 males; mean age, 51.

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  • * Patients classified by circadian phase indicated that those with late-phase timings reported more severe insomnia symptoms and longer sleep latency compared to early-phase participants.
  • * The findings suggest that actigraphy-derived patterns and circadian phase may aid in interpreting polysomnography (PSG) results and contribute to understanding insomnia mechanisms.
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Objective: We aimed to investigate relationships between sleep disturbances and phenoconversion to neurodegenerative diseases in patients with REM sleep behavior disorder (RBD).

Method: Using a comprehensive sleep database in a university-affiliated hospital between December 2014 and March 2021, we reviewed the data of 226 patients with RBD (182 patients with idiopathic RBD (iRBD) and 44 patients with symptomatic RBD (sRBD) with a neurodegenerative disease).

Results: Among 226 patients with RBD (male, 61.

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Background And Purpose: Individualized anti-epileptic drug (AED) selection in patient with epilepsy is crucial. However, there is no unified opinion in treating patients with drug resistant epilepsy (DRE). This survey aimed to make a consolidate consensus with epileptologists' perspectives of the treatment for Korean DRE patients by survey responses.

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Background And Objective: Subtraction of ictal SPECT coregistered to MRI (SISCOM) provides complementary information for detecting the ictal onset zone, especially in patients with MRI-negative focal epilepsy, and provides additional useful information for predicting long-term postresection outcomes. This study sought to investigate the relationship between surgical failure and increased cerebral blood flow (CBF) pattern using SPECT in patients with mesial temporal lobe epilepsy with unilateral hippocampal sclerosis (MTLE-HS).

Methods: Among 42 subjects who underwent anterior temporal lobectomy with amygdalohippocampectomy (ATL-AH) for MTLE-HS, 29 (69.

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  • Abnormal brain discharges during seizures can disrupt autonomic functions, potentially leading to cardiac issues and sudden deaths in epilepsy.
  • This study compared cardiac autonomic functions in patients with temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE) by analyzing heart rate variability (HRV) before, during, and after seizures.
  • Results indicated significant differences in heart rate parameters between the two epilepsy types, with TLE patients exhibiting sustained sympathetic activity while FLE patients showed fluctuations in sympathetic responses during seizures.
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Objective: Organic light-emitting diodes (OLEDs) emit less blue light than traditional light-emitting diodes (LEDs), and we previously found that early-night OLED light exposure (LE) delays the melatonin phase by less than LED at a color temperature of 4,000 K. As a follow-up study, we investigated the effects of OLED and LED at a different color temperature (3,000 K) on melatonin profile, sleep, and vigilance.

Methods: 24 healthy subjects (27.

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Background And Purpose: Organic light-emitting diodes (OLEDs) emit less blue light than traditional light-emitting diodes (LEDs), but the effects of OLED light exposure (LE) on melatonin and sleep have not been evaluated.

Methods: Twenty-four healthy subjects (age 26.9±5.

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We aimed to identify an Alzheimer's disease (AD) subtype with right predominant focal atrophy. We recruited 17 amyloid PET positive logopenic variant primary progressive aphasia (lvPPA) and 226 amyloid PET positive AD patients. To identify AD with right focal atrophy (Rt-AD), we selected cortical areas that showed more atrophy in lvPPA than in AD and calculated an asymmetry index (AI) for this area in each individual.

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Alzheimer's disease patients with presenilin 1 (PSEN1) mutations commonly show parkinsonism in addition to dementia. Yet, whether these patients show dopaminergic deficit and response to L-dopa is largely unknown. We report a 43-year-old woman with a PSEN1 mutation (A434T) who showed right side dominant parkinsonism.

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Purpose Of Study:  Standard treatment protocols for lumbar degenerative lesions in the setting of rheumatoid arthritis (RA) are lacking. The purpose of this study was to evaluate the clinical and radiologic outcomes of minimally invasive oblique lumbar interbody fusion (MI-OLIF) in RA patients having degenerative lumbar spine lesions.

Methods:  This was a retrospective hospital-based case series (evidence level 4).

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  • The study compares the outcomes of Oblique Lumbar Interbody Fusion (OLIF) and Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF) in patients without laminectomy.
  • Results showed that OLIF had less blood loss, shorter surgical time, and better restoration of disc height (DH), while both methods improved pain and disability scores similarly.
  • OLIF achieved faster fusion rates compared to MI-TLIF, suggesting it might be the better option for patients with minimal stenosis.
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Most database search tools for proteomics have their own scoring parameter sets depending on experimental conditions such as fragmentation methods, instruments, digestion enzymes, and so on. These scoring parameter sets are usually predefined by tool developers and cannot be modified by users. The number of different experimental conditions grows as the technology develops, and the given set of scoring parameters could be suboptimal for tandem mass spectrometry data acquired using new sample preparation or fragmentation methods.

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Article Synopsis
  • Fusion is crucial for treating unstable degenerative lumbar spinal disease, with techniques like oblique lumbar interbody fusion (OLIF) offering benefits such as minimal risk to surrounding muscles and nerves.
  • OLIF allows for effective restoration of disc height and spinal alignment but poses risks due to its anatomical placement near major blood vessels and the ureter, leading to potential vascular and urologic complications.
  • The article aims to review common complications of the OLIF procedure at spinal levels L2-L5 and provide technical advice to mitigate these risks.
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Prenatal ultrasonography (US) in a 39 year-old woman revealed massive fetal ascites. A fetal abdomino-amniotic shunting procedure was performed. Subsequently, plain radiographs demonstrated diffuse gaseous distention of the bowel and multiple punctate calcifications in the left upper abdomen.

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Cervical spondylotic myelopathy (CSM) is the most common degenerative disease of the spine in elderly patients. Although there are several surgical options for the treatment of this disease, minimally invasive techniques for localized decompression of the true clinical generator of the patient's disease has revolutionized spinal surgery recently. This article presents an alternate application of the anterior transcorporeal tunnel approach in combination with computed tomography (CT)-based intraoperative navigation in the treatment of patients with cervical myelopathy secondary to spondylosis.

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