Publications by authors named "Hyunho Lee"

Background: Antipsychotic drugs (APDs) are used for treating mental illnesses and are also used by cancer patients. This study aimed to evaluate APD use in adult cancer patients who received radiotherapy (RT) in South Korea and assess the effects of APD use during RT on survival.

Methods: This retrospective cohort study utilized the National Health Insurance Service database database of Korea.

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Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited therapeutic options. Cisplatin is a primary chemotherapeutic agent utilized in combination with other drugs or radiotherapy for PDAC treatment. However, the severe side effects of cisplatin often necessitate discontinuation of therapy and drug resistance in tumor cells poses significant clinical challenges.

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  • * Out of 170,226 patients, only 3361 (1.97%) received APDs, and overall findings showed that APD use was linked to higher mortality rates among these patients, including those without metastasis.
  • * Interestingly, patients with a prior psychiatric history and long-term APD use had lower mortality, while those starting APDs during radiotherapy experienced higher mortality, indicating that the reasons for APD use may play a significant role in patient outcomes.
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  • * The isolated virus from the cats and raw food belonged to the HPAI A(H5N1) clade 2.3.4.4b, showing similarities to previously isolated viruses in Korea from November 2022.
  • * Infected cats exhibited severe systemic lesions and harbored mutations indicating adaptation to mammals, leading to symptoms and death from consuming contaminated raw meat.
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  • Positive aging significantly improves the electroluminescence characteristics of quantum-dot light-emitting diodes (QLEDs) by enhancing electron transport and reducing exciton quenching at the interfaces.
  • The use of ultraviolet-curable resin in encapsulation helps delay harmful reactions at the aluminum and zinc magnesium oxide interface, leading to better device performance over time.
  • The study revealed that after 120 hours, the external quantum efficiency of indium phosphide (InP) QLEDs increased from 3.16% to 12.04%, showcasing the positive aging effect and providing insights into the operating mechanisms of aging agents in QLEDs.
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CRISPR prime editing () requires a Cas9 nickase-reverse transcriptase fusion protein (known as PE2) and a prime editing guide RNA (), an extended version of a standard guide RNA () that both specifies the intended target genomic sequence and encodes the desired genetic edit. Here, we show that sequence complementarity between the 5' and the 3' regions of a pegRNA can negatively impact its ability to complex with Cas9, thereby potentially reducing PE efficiency. We demonstrate this limitation can be overcome by a simple pegRNA refolding procedure, which improved ribonucleoprotein-mediated PE efficiencies in zebrafish embryos by up to nearly 25-fold.

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B cell receptors (BCRs) denote antigen specificity, while corresponding cell subsets indicate B cell functionality. Since each B cell uniquely encodes this combination, physical isolation and subsequent processing of individual B cells become indispensable to identify both attributes. However, this approach accompanies high costs and inevitable information loss, hindering high-throughput investigation of B cell populations.

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Work-related musculoskeletal disorders represent a major occupational disability issue, and 53.4% of these disorders occur in the back or shoulders. Various types of passive shoulder exoskeletons have been introduced to support the weight of the upper arm and work tools during overhead work, thereby preventing injuries and improving the work environment.

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  • A traumatic avulsion fracture of the distal phalanx of the hallux, known as bony mallet toe, is a rare condition with no established treatment methods.
  • A case study of a 54-year-old man treated this condition with screw fixation and strong sutures, which improved the stability of the area.
  • After 20 months, the patient experienced no symptoms or complications, demonstrating the effectiveness of this new surgical technique.
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Herein, we report the identification, structural optimization, and biological efficacy of thieno[2,3-]pyridines as potent inhibitors of splice variants of the tyrosine kinase recepteur d'origine nantais (RON). Among synthesized compounds, compound exhibited excellent kinase inhibition and antiproliferative activity, as well as antineoplastic efficacy against RON splice variant-expressing tumors. Moreover, compound with excellent pharmacokinetics demonstrated significant activity with greater tumor growth inhibition (74.

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Background: Obtaining an accurate tibial lateral view is important during high tibial osteotomy. This study investigated whether the posterior edge of the medial/lateral tibial condyle (PEMTC/PELTC) and the posterior edge of the fibular head (PEFH) in a lateral view could be a reference for determining the accurate tibial lateral view.

Methods: A total of 75 lower limbs in 38 subjects were evaluated in this study.

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CRISPR prime editing () requires a Cas9 nickase-reverse transcriptase fusion protein (known as PE2) and a prime editing guide RNA (), an extended version of a standard guide RNA () that both specifies the intended target genomic sequence and encodes the desired genetic edit. Here we show that sequence complementarity between the 5' and the 3' regions of a pegRNA can negatively impact its ability to complex with Cas9, thereby potentially reducing PE efficiency. We demonstrate this limitation can be overcome by a simple pegRNA refolding procedure, which improved ribonucleoprotein-mediated PE efficiencies in zebrafish embryos by up to nearly 25-fold.

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Fibroblast-to-myofibroblast transition (FMT) leads to excessive extracellular matrix (ECM) deposition-a well-known hallmark of fibrotic disease. Transforming growth factor-β (TGF-β) is the primary cytokine driving FMT, and this phenotypic conversion is associated with mitochondrial dysfunction, notably a metabolic reprogramming towards enhanced glycolysis. The objective of this study was to examine whether the establishment of favorable metabolic phenotypes in TGF-β-stimulated fibroblasts could attenuate FMT.

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In urban areas, particulate matter emitted from vehicles directly affects the health of citizens near roads. Thus, in this study, particle size distribution was measured by the horizontal and vertical distances along a highway road with heavy traffic to characterize the dispersion phenomena of particulate matter emitted from vehicles. In addition, the contribution of pollution sources was analyzed using a source-receptor model.

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An innovative approach to fabricate transparent and redispersible α-chitin nanocrystals (ChNCs) with high overall yields was developed in this work for eventual commercial use. The nanomanufacturing process included electron-beam irradiation (EBI) of chitin for oxidation and degradation in the dried state, high-pressure nanoscale homogenization swelling, CO absorption, and spray-drying to obtain dehydrated products. The resulting EBI-disassociated chitins contained increased amounts of carboxylate (0.

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mRNA delivery enables the specific synthesis of proteins with therapeutic potential, representing a powerful strategy in diseases lacking efficacious pharmacotherapies. Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by excessive extracellular matrix (ECM) deposition and subsequent alveolar remodeling. Alveolar epithelial type 2 cells (AEC2) and fibroblasts represent important targets in IPF given their role in initiating and driving aberrant wound healing responses that lead to excessive ECM deposition.

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We assessed the efficacy of a 4-week nurse-led exercise rehabilitation (ER) program in improving the quality of life (QOL) of breast cancer survivors (BCS) receiving an implant-based breast reconstruction. The eligible patients were equally randomized to either of both groups: the intervention group ( = 30; a 4-week nurse-led ER program) and the control group ( = 30; a 4-week physical therapist-supervised one). Both after a 4-week ER program and at baseline, the patients were evaluated for the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Fatigue Severity Scale (FSS) scores.

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Despite recent rapid advances in improving quantum dot light-emitting diodes, many fundamental aspects of the device operating mechanism remain unresolved. Through transient electroluminescence and time-resolved photoluminescence measurements, the effects of offset voltage on charging and charge transport are examined. First, capacitive charging occurs with a time constant of ∼500 ns, followed by electron transport through quantum dots with a mobility of ∼10 cm V s.

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The stability of methylammonium (MA)-based perovskite solar cells (PSCs) remains one of the most urgent issues that need to be addressed. Inherent weak binding forces between MAs and halides cause the perovskite structure to become unstable under exposure to various external environmental factors such as moisture, oxygen, ultraviolet radiation, and heat. In particular, the degradation of perovskite films under light exposure accelerates the deterioration of the device, mainly due to the migration of halide ions.

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Alzheimer's disease (AD) is the most prevalent type of dementia. Reports have revealed that the peripheral immune system is linked to neuropathology; however, little is known about the contribution of B lymphocytes in AD. For this longitudinal study, 133 participants are included at baseline and second-year follow-up.

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B cells recognize antigens via membrane-expressed B-cell receptors (BCR) and antibodies. Similar human BCR sequences are frequently found at a significantly higher frequency than that theoretically calculated. Patients infected with SARS-CoV2 and HIV or with autoimmune diseases share very similar BCRs.

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Article Synopsis
  • Interest in quantum dot light-emitting diodes (QLEDs) is growing due to their potential in improving display devices and light sources.
  • This study analyzes transient electroluminescence (TREL) signals from dichromatic QLEDs, which have two different color-emitting QD layers, to understand charge injection and exciton recombination.
  • The research also measures electron mobility and explores energy transfer and exciton quenching effects, aiming to enhance the understanding and performance of QLEDs.
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  • Epitranscriptomic features, like single-base RNA editing, contribute to transcript diversity in cancer, but their spatial context in tumors is poorly understood.
  • The study introduces a method called Select-seq, which combines spatial-histopathological examination with transcriptomic sequencing to analyze regions of interest in tissue samples.
  • Using Select-seq, researchers focus on cancer stem cell-like microniches in triple-negative breast cancer to identify alternative splice variants and specific RNA editing patterns, particularly adenosine-to-inosine changes unique to different microniche groups.
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Dispersion of nanofillers in a polymer matrix is one of the most important steps in preparing polymer nanocomposites. However, hydrophobic polymers and hydrophilic nanofillers are intrinsically incompatible, making it difficult to mix them homogeneously. Here, we propose the swelling-based particle adsorption method (SPA) providing a simple route to disperse cellulose nanofibrils (CNFs) within incompatible polypropylene (PP) matrix without surface functionalization of CNFs.

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