Regulatory effects of extract and Diphlorethohydroxycarmalol on skin barrier function.

Ethnopharmacological Relevance: The pharmacological potential of marine organisms remains largely unexplored. commonly known as Pae, is extensively distributed over Asia. Its antioxidant, antibacterial, antiobesity, and anti-inflammatory properties are also being investigated.

7-MEGA™ inhibits adipogenesis in 3T3-L1 adipocytes and suppresses obesity in high-fat-diet-induced obese C57BL/6 mice.

Background: Overweight, often known as obesity, is the abnormal and excessive accumulation of fat that exposes the health of a person at risk by increasing the likelihood that they may experience many chronic conditions. Consequently, obesity has become a global health threat, presenting serious health issues, and attracting a lot of attention in the healthcare profession and the scientific community.

Method: This study aims to explore the anti-adipogenic properties of 7-MEGA™ in an attempt to address obesity, using both in vitro and in vivo research.

Effect of (Maxim.) Trautv extract on a model of atopic dermatitis in HaCaT cells and mice.

(Maxim.) Trautv. has been used for a long time as a folk remedy.

Interferon-β alleviates sepsis by SIRT1-mediated blockage of endothelial glycocalyx shedding.

Sepsis is a life-threatening multi-organ dysfunction with high mortality caused by the body's improper response to microbial infection. No new effective therapy has emerged that can adequately treat patients with sepsis. We previously demonstrated that interferon-β (IFN-β) protects against sepsis via sirtuin 1-(SIRT1)-mediated immunosuppression.

Effects of extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation.

is an edible crop and herbal medicine that is known to have antipyretic, anti-inflammatory, and anti-edema effects. Many studies have been conducted on the 95% ethanol extract of , but there is little research on the 70% ethanol extract and hemiphloin, which is a new indicator component of the 70% ethanol extract of . To investigate the anti-atopic effect and verify the mechanism action of 70% ethanol extract of (VAE), TNF-α/IFN-γ-induced HaCaT keratinocytes were used.

Spectral noise and data reduction using a long short-term memory network for nonlinear ultrasonic modulation-based fatigue crack detection.

This paper presents a spectral noise and data reduction technique based on long short-term memory (LSTM) network for nonlinear ultrasonic modulation-based fatigue crack detection. The amplitudes of the nonlinear modulation components created by a micro fatigue crack are often very small and masked by noise. In addition, the collection of large amounts of data is often undesirable owing to the limited power, data storage, and data transmission bandwidth of monitoring systems.

Regulatory Effects of Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation.

and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-)/interferon gamma (IFN-). The inhibitory activity of EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated.

Anti-Osteoporotic Effects of -Hibiscusamide and Its Derivative Alleviate Ovariectomy-Induced Bone Loss in Mice by Regulating RANKL-Induced Signaling.

Osteoporosis is characterized by the deterioration of bone structures and decreased bone mass, leading to an increased risk of fracture. Estrogen deficiency in postmenopausal women and aging are major factors of osteoporosis and are some of the reasons for reduced quality of life. In this study, we investigated the effects of -hibiscusamide (NHA) and its derivative 4--()-feruloyl--()-hibiscusamide (HAD) on receptor activator of nuclear factor kappa-Β (NF-κB) ligand (RANKL)-induced osteoclast differentiation and an ovariectomized osteoporosis mouse model.

Changes in the phosphorylation of nucleotide metabolism‑associated proteins by leukemia inhibitory factor in mouse embryonic stem cells.

Leukemia inhibitory factor (LIF) is a stem cell growth factor that maintains self‑renewal of mouse embryonic stem cells (mESCs). LIF is a cytokine in the interleukin‑6 family and signals via the common receptor subunit gp130 and ligand‑specific LIF receptor. LIF causes heterodimerization of the LIF receptor and gp130, activating the Janus kinase/STAT and MAPK pathways, resulting in changes in protein phosphorylation.

Eudebeiolide B Inhibits Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Regulating RANKL-Induced NF-κB, c-Fos and Calcium Signaling.

Eudebeiolide B is a eudesmane-type sesquiterpenoid compound isolated from R. Br., and little is known about its biological activity.

Beneficial effects of extract in osteoporosis and osteoarthritis.

In Asia, (azuki bean) has been used as a traditional medicine to treat various diseases because of its biological properties. Osteoarthritis (OA) and osteoporosis (OP) are common regenerative bone diseases that are characterized by deterioration of joint and bone structure. In this study, we evaluated the effects of extract (VAE) on monosodium iodoacetate (MIA)-induced OA and ovariectomy (OVX)-induced OP models.

Retrofractamide C Derived from Alleviates Xylene-Induced Mouse Ear Edema and Inhibits Phosphorylation of ERK and NF-κB in LPS-Induced J774A.1.

Many studies have reported the biological activities of retrofractamide C (RAC). However, few studies have investigated the anti-inflammatory effect of RAC. In the present study, we investigated the anti-inflammatory effect of RAC using lipopolysaccharide (LPS)-induced J774A.

Acyclic Triterpenoid Isolated from Alleviates Formalin-Induced Chronic Mouse Paw Inflammation by Inhibiting the Phosphorylation of ERK and NF-κB.

Chronic and excessive inflammation can destroy host organs and cause inflammatory diseases such as inflammatory bowel disease, asthma, and rheumatoid arthritis. In this study, we investigated the anti-inflammatory effects of seed-derived 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (PHT) using lipopolysaccharide (LPS)-stimulated J774 cells and a formalin-induced chronic paw inflammation mouse model. The in vitro results showed that PHT exhibited no cytotoxicity and decreased LPS-induced NO secretion.

Oleanolic Acid Acetate Exerts Anti-Inflammatory Activity via IKKα/β Suppression in TLR3-Mediated NF-κB Activation.

Oleanolic acid acetate (OAA), a major triterpenoid compound of (azuki bean, ), has been shown to downregulate inflammatory responses in macrophages. Here, we show the molecular basis for the effect of OAA on Toll-like receptor (TLR) downstream signaling. OAA treatment significantly inhibited the secretion of embryonic alkaline phosphatase (SEAP) induced by polyinosinic acid (poly(I), TLR3 ligand) in a dose-dependent manner and without cytotoxicity in THP1-XBlue cells.

STAT3-inhibitory activity of sesquiterpenoids and diterpenoids from Curcuma phaeocaulis.

Three new sesquiterpenoids (compounds 4, 5, and 26), along with 23 known sesquiterpenoids (compounds 1-3 and 6-25) and two diterpenoids (compounds 27 and 28), were obtained from Curcuma phaeocaulis, and their chemical structures were determined through nuclear magnetic resonance (NMR), circular dichroism (CD), and high-resolution electrospray ionization (HRESIMS) spectroscopic data, which were compared to the data from previous studies. All isolates were tested for inhibitory activity against interleukin (IL)-6-stimulated STAT3 expression using a luciferase reporter assay, and curzerenone (21) and 8-epi-galanolactone (28) displayed promising signal transducer and activator of transcription (STAT3)-inhibitory activities with IC values of 4.8 and 4.

Adaptive Ground Control System of Multiple-UAV Operators in a Simulated Environment.

In the present study, an Adaptive Ground Control System for Multiple-UAV Operator Workload Decrement (AGCS) has been developed and the effectiveness of the system has been analyzed using eye-tracking and task performance data. The AGCS contained four more functions than the conventional GCS (CGCS) functions. The functions were based on real-time operator gaze information, multiple UAV operational state, and mission state information to help safe and efficient multiple UAV operation.

In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.

Many studies have identified and described various medicinal effects of cirsiliol. Here, we investigated the signaling pathway involved in the anti-inflammatory effects of cirsiliol on IL-6-induced activity. Cirsiliol showed no cytotoxicity and inhibited pSTAT3-induced luciferase activity.

Diarylheptanoids from Curcuma phaeocaulis Suppress IL-6-Induced STAT3 Activation.

Three undescribed diarylheptanoids (3: -5: ) and six known curcuminoids (1, 2: , and 6: -9: ) were obtained from the ethyl acetate-soluble fraction of an ethanolic extract of . Their chemical structures and absolute configurations were elucidated by high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, circular dichroism spectroscopy, and the modified Mosher's method. Previous studies constructed Hep3B cells stably transfected with pSTAT3-Luc plasmid containing STAT3 binding site to discover STAT3 inhibitors from natural products.

Inhibitory Effects of Compounds and Extracts from on IL-6-Induced STAT3 Activation.

(Maxim.) Trautv. (AB), a traditional East Asian medicine, exhibits protective effects against several inflammatory diseases.

Portulaca oleracea extracts and their active compounds ameliorate inflammatory bowel diseases in vitro and in vivo by modulating TNF-α, IL-6 and IL-1β signalling.

Portulaca oleracea L. (P. oleracea) is an herb that is widely used in traditional medicine to treat various diseases.

Anti-inflammatory Activity of Eudesmane-Type Sesquiterpenoids from Salvia plebeia.

Nine new sesquiterpenoid lactones and 11 known analogues were isolated from the aerial parts of Salvia plebeia R.Br. Their structures were elucidated via HRESIMS and NMR data, and their absolute configurations were defined via electronic circular dichroism data, X-ray crystallographic analysis, and the modified Mosher's ester method.

Necessary Conditions for Nonlinear Ultrasonic Modulation Generation Given a Localized Fatigue Crack in a Plate-Like Structure.

It has been shown that nonlinear ultrasonics can be more sensitive to local incipient defects, such as a fatigue crack, than conventional linear ultrasonics. Therefore, there is an increasing interest in utilizing nonlinear ultrasonics for structural health monitoring and nondestructive testing applications. While the conditions, which are the necessary conditions that should be satisfied for the generation of nonlinear harmonic components, are extensively studied for distributed material nonlinearity, little work has been done to understand the necessary conditions at the presence of a localized nonlinear source such as a fatigue crack.

Schwann Cell Precursors from Human Pluripotent Stem Cells as a Potential Therapeutic Target for Myelin Repair.

Schwann cells play a crucial role in successful nerve repair and regeneration by supporting both axonal growth and myelination. However, the sources of human Schwann cells are limited both for studies of Schwann cell development and biology and for the development of treatments for Schwann cell-associated diseases. Here, we provide a rapid and scalable method to produce self-renewing Schwann cell precursors (SCPs) from human pluripotent stem cells (hPSCs), using combined sequential treatment with inhibitors of the TGF-β and GSK-3 signaling pathways, and with neuregulin-1 for 18 days under chemically defined conditions.

Reference-free damage detection, localization, and quantification in composites.

In this study, a reference-free damage characterization technique is developed not only to identify but also to locate and quantify damage in composite structures subject to varying temperature conditions. First, damage is characterized in terms of a damage index (m-value) defined as the ratio of damage size to the wavelength of the A0 mode within the damage. Then, a feasible solution space defining all possible combinations of the damage location and size are estimated without using any prior baseline data obtained from the pristine condition of a structure or different paths.