Increased expression of L-amino acid transporters in balloon cells of tuberous sclerosis.

Objects: Tuberous sclerosis complex (TSC) is a dysgenetic syndrome involved in multiple organs, and the pathognomonic cortical tuber act as an epileptic substrate. The amino acid transport system L (LAT) is a major nutrient transport system, and LAT1 is highly expressed in malignant tumors to support tumor cell growth. To study the life-long epilepsy from the cortical tuber, the expression of LAT1 in balloon cells and dysplastic neurons of the cortical tuber is investigated.

Clinical features and epileptogenesis of dysembryoplastic neuroepithelial tumor.

Introduction: Dysembryoplastic neuroepithelial tumor (DNT) frequently causes medically intractable epilepsy.

Objective: The aim of this study was to investigate the basic mechanism of epileptogenecity of the tumor.

Materials And Methods: Clinicopathological data in 13 cases of DNT and immunohistochemical changes of ionotropic glutamate receptor subunits in the tumor and peritumoral epileptogenic cortex were studied.

Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study.

Atypical teratoid/rhabdoid tumor (AT/RT) is a new entity among malignant pediatric brain tumors. This study was performed to investigate the clinicopathologic and cytogenetic features of the tumor. Five cases from a series of the brain tumors were studied.