Ubiquitin E3 ligases in cancer: somatic mutation and amplification.

Defects in DNA double-strand break (DSB) repair signaling permit cancer cells to accumulate genomic alterations that confer their aggressive phenotype. Nevertheless, tumors depend on residual DNA repair abilities to survive the DNA damage induced by genotoxic stress. This is why only isolated DNA repair signaling is inactivated in cancer cells.

Ileocolic Intussusception Accompanied with Inflamed Appendix: 2 Case Reports.

Intussusception and acute appendicitis are common emergency conditions in children. They should be promptly differentiated in pediatric patients presenting with suggestive symptoms. However, both diseases may occur simultaneously.

Prone position [F]FDG PET/CT to reduce respiratory motion artefacts in the evaluation of lung nodules.

Objectives: 2-Deoxy-2-[F]fluoro-D-glucose ([F]FDG) positron-emission tomography/computed tomography (PET/CT) is widely used to evaluate lung nodules, although respiratory motion artefacts may occur. We investigated the value of prone position PET/CT (pPET/CT) in lung nodule evaluation compared with standard supine position PET/CT (sPET/CT).

Methods: We retrospectively reviewed 28 consecutive patients (20 men; age, 65.

Right hydronephrosis as a sign of complicated appendicitis.

Objective: Acute appendicitis is known for one of the most common cause of acute abdomen. However, it is still challenging to clearly distinguish complicated from uncomplicated appendicitis preoperatively. We investigated the association between right hydronephrosis and complicated appendicitis compared with other computed tomography (CT) findings of acute appendicitis.

Clinical and Radiologic Findings of COVID-19 Pneumonia: South Korean Experience From Three Cases.

Coronavirus disease 2019 (COVID-19) is spreading rapidly around the world. Several articles have so far reported on radiological findings of COVID-19 pneumonia. Herein, we present three cases of COVID-19 pneumonia in South Korea, and provide clinical information as well as chest radiograph and chest CT findings.

A Newly Isolated Bacteriophage, PBES 02, Infecting Cronobacter sakazakii.

A novel bacteriophage, PBES 02, infecting Cronobacter sakazakii was isolated and characterized. It has a spherical head of 90 nm in diameter and a tail of 130 nm in length, and belongs to Myoviridae as observed under a transmission electron microscope. The major virion protein appears to be 38 kilodaltons (kDa) in size.

The efficacy of TachoComb on reducing postoperative complications after tonsillectomy in children.

Objective: A fibrinogen/thrombin-based collagen fleece (TachoComb) is a powerful topical hemostatic agent that has been widely used in various surgical specialties with a favorable outcome. The purpose of this study was to investigate the effect of TachoComb application on postoperative complications after tonsillectomy.

Materials And Methods: A total of 1633 children had undergone tonsillectomy with or without adenoidectomy were included in this study.