Publications by authors named "Hyunchang Ko"
Hereditary hypotrichosis simplex with SNRPE gene mutation.
Indian J Dermatol Venereol Leprol
November 2024
The utility of dermoscopy for the diagnosis of cutaneous warts is well known. However, its role in predicting the outcome of cryotherapy for cutaneous warts remains unexplored. To identify dermoscopic features predicting treatment responses in cryotherapy for cutaneous warts.
View Article and Find Full Text PDFTreatment With Upadacitinib in Refractory Prurigo Nodularis: A Prospective Cohort Study.
Allergy Asthma Immunol Res
September 2024
Article Synopsis
- Prurigo nodularis (PN) is a chronic skin condition characterized by severe itching that often does not respond well to standard treatments.
- A study evaluated the effectiveness of upadacitinib, a medication taken daily for 24 weeks, in 10 patients who had not improved with previous treatments, specifically cyclosporine.
- Results showed significant reductions in itching and overall skin condition severity, with no severe side effects, suggesting that upadacitinib is a promising option for managing refractory PN.
Article Synopsis
- Mesenchymal stem cells (MSCs) have potential in medical therapies due to their ability to modulate immune responses, and this study focused on their use in treating atopic dermatitis (AD).
- A phase 1 trial confirmed the safety of allogenic human bone marrow-derived clonal MSCs (hcMSCs) in patients, leading to a phase 2 trial that showed hcMSC treatment resulted in improved eczema severity after 12 weeks compared to a placebo.
- Despite some mild adverse effects, hcMSC therapy had an acceptable safety profile, suggesting it could be effective, though further extensive research is needed to validate these initial findings.
Dermoscopic Features of Subcorneal Hematoma on the Palms and Soles: Differences from Acral Melanoma.
Acta Dermatovenerol Croat
December 2023
Background: The diagnosis of subcorneal hematoma (SH) can be challenging because the clinical presentation of SH can resemble melanocytic lesions. Few studies have examined the characteristic dermoscopic features of SH, but a more detailed large-scale study is needed to overcome the diagnostic challenge of differentiating it from acral melanoma.
Objectives: To describe the dermoscopic features of SH.
Background: Annually, 175.4 million people are infected with scabies worldwide. Although parasitic infections are important nosocomial infections, they are unrecognized compared to bacterial, fungal, and viral infections.
View Article and Find Full Text PDFHidradenitis suppurativa (HS) is an inflammatory disorder characterized by chronic deep-seated nodules, abscesses, fistulae, sinus tracts, and scars in apocrine gland-bearing regions. Assessing its severity is challenging because of its clinical heterogeneity, lack of a standardized tool, and increasing severity scores. This article provides a chronological overview of HS grading scales to aid in the understanding and comparison of different scoring systems.
View Article and Find Full Text PDFThe Psoriasis Area and Severity Index (PASI) 100 response rate after treatment with biologics is reportedly lower in Asians than non-Asians. Large-scale studies evaluating predictors of PASI 100 response in Korean patients with psoriasis are yet to be conducted. To identify predictors of patients achieving PASI 100 response after 48-52 weeks of treatment with a biological agent.
View Article and Find Full Text PDFAssociation between the skin microbiome and lichen striatus hypopigmentation: Cutibacterium acnes as a potential cause.
J Eur Acad Dermatol Venereol
September 2024
Article Synopsis
- Lichen striatus (LS) is a skin disorder usually seen in children, characterized by lesions that follow the skin's natural lines and often disappear on their own within months.
- The study investigates why about half of LS patients experience long-lasting hypopigmentation, analyzing differences in the skin microbiome between those with and without this effect.
- Findings show that certain bacteria, like Cutibacterium acnes, are more common in LS patients with hypopigmentation, suggesting the skin microbiome could play a role in this condition and may be a target for treatments.
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma accounting for approximately one-third of all cases. DLBCL can present as a lymph node or extranodal tumor. Cavernous sinus (CS) is a small but complex structure in which various arteries, sympathetic plexuses, and cranial nerves are passing through.
View Article and Find Full Text PDFNail apparatus changes following upper limb casting or splinting.
J Eur Acad Dermatol Venereol
May 2024
Psoriasis is a common immune-mediated, inflammatory skin disease. However, unilateral psoriasis is rare and few cases have been reported. A 59-year-old male with a polio-affected right leg presented with exfoliative skin on the left leg for three months.
View Article and Find Full Text PDFQ-switched neodymium-yttrium aluminum-garnet (Q-switched Nd:YAG) laser has been reported as an effective treatment for nevus of Ota and acquired bilateral nevus of Ota-like macules (ABNOM). Data on ectopic Mongolian spots have rarely been reported.The present study was performed to investigate the treatment efficacy of a high-fluence 1064 nm Q-switched Nd:YAG laser without tissue whitening in ectopic Mongolian spots.
View Article and Find Full Text PDFJanus kinase (JAK) inhibitors have been recently approved by the FDA and are widely used in the treatment of patients with atopic dermatitis. However, a comprehensive safety profile of JAK inhibitors in patients with atopic dermatitis has not been analysed. This study aimed to establish clinical evidence for the safety of systemic JAK inhibitors in patients with atopic dermatitis.
View Article and Find Full Text PDFAtopic dermatitis is the most common chronic inflammatory skin disease affecting children. Some studies have reported a higher risk of atopic dermatitis in urban areas than in rural areas. We systematically reviewed and carried out a meta-analysis to investigate the differences in the development of atopic dermatitis between urban and rural areas.
View Article and Find Full Text PDFArticle Synopsis
- Pigmented fungiform papillae of the tongue (PFPT) is a rare benign disorder mainly observed in darker-skinned individuals, but its occurrence in Koreans had limited research prior to this study.
- This study analyzed 19 Korean patients diagnosed with PFPT from 1995-2021, revealing a higher prevalence in females and an average diagnosis age of 41.1 years.
- Findings also indicated that PFPT often coincides with other pigmentary disorders and common dermoscopic patterns observed were the rose petal and cobblestone patterns; sex hormones may play a role in its development.