Acute myeloid leukemia and myelodysplastic neoplasms: clinical implications of myelodysplasia-related genes mutations and TP53 aberrations.

Purpose: The fifth World Health Organization (WHO) classification (2022 WHO) and International Consensus Classification (ICC) of myeloid neoplasms have recently been published. In this study, patients were reclassified according to the revised classification and their prognoses were analyzed to confirm the clinical utility of the new classifications.

Methods: We included 101 adult patients, 77 with acute myeloid leukemia (AML) and 24 with myelodysplastic neoplasms (MDS), who underwent bone marrow aspiration and next-generation sequencing (NGS) between August 2019 and July 2023.

Determination of Flavonoid Glycoside Isomers Using Vision Transformer and Tandem Mass Spectrometry.

A vision transformer (ViT)-based deep neural network was applied to classify the flavonoid glycoside isomers by analyzing electrospray ionization tandem mass spectrometry (ESI-MS/MS) spectra. Our model successfully classified the flavonoid isomers with various substitution patterns (3-O, 6-C, 7-O, 8-C, 4'-O) and multiple glycosides, achieving over 80% accuracy during training. In addition, the experimental spectra from flavonoid glycoside standards were acquired with different adducts, and our model showed robust performance regardless of the experimental conditions.

Porphyrinic N channels of zinc ions for the electrochemical reversibility of zinc plating/stripping.

A Zn-coordinated porphyrinic artificial solid-electrolyte interphase (αSEI) layer, named [Zn]PP-4COO-(Zn), was developed to improve the reversibility of zinc metal plating/stripping in aqueous zinc-ion batteries (ZIBs). Inspired by nitrogen-terminating sites of biological molecules coordinating and transporting zinc in zinc metabolic processes, the αSEI layer was designed with zinc ions connecting porphyrinic building blocks to form two-dimensional clathrate sheets and stacking -plane sheets along the -axis to allow N cages to align and form porphyrinic N channels for zinc transport. The [Zn]PP-4COO-(Zn) αSEI layer was Zn-conductive and structurally durable during repeated stripping/plating.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Wound healing effect of fucoidan-loaded gelatin/oxidized carboxymethyl cellulose hydrogel.

Various wound dressings are under development to accelerate wound healing, and hydrogels in particular have the potential to create ideal conditions for wound healing. In this study, we investigated a novel hydrogel based on gelatin/oxidized carboxymethyl cellulose loaded with fucoidan derived from Ecklonia cava (ECF) for wound treatment. The mechanical stability and self-healing ability of the hydrogel were optimized, and its cytocompatibility was demonstrated against RAW 264.

Copper-Catalyzed Regioselective and Enantioselective Hydropyridylation of Dienes for the Synthesis of Chiral Diaryl Compounds via Concerted Nucleophilic Aromatic Substitution.

The synthesis of chiral 1,1-diaryl compounds, particularly those containing a pyridine moiety, is of significant interest due to their pharmaceutical applications. Here, we report the development of a copper-catalyzed enantioselective 1,4-hydropyridylation of conjugated dienes. Utilizing 2-fluoropyridine as the electrophile, CuOAc, and the chiral ligand Tol-BINAP, we optimized reaction conditions to achieve the desired chiral 1,1-diaryl products containing both a pyridine and a cis-crotyl group.

Marine polysaccharides for antibiofilm application: A focus on biomedical fields.

Microbial pathogens such as bacteria and fungi form biofilms, which represent substantial hurdles in treating human illness owing to their adaptive resistance mechanism to conventional antibiotics. Biofilm may cause persistent infection in a variety of bodily areas, including wounds, oral cavity, and vaginal canal. Using invasive devices such as implants and catheters contributes significantly to developing healthcare-associated infections because they offer an ideal surface for biofilm formation.

Local Stiffness Measurement of Hepatic Steatosis Model Liver Organoid by Fluorescence Imaging-Assisted Probe Indentation.

Mechanical stiffness of liver organoid is a key indicator for the progress of hepatic steatosis. Probe indentation is a noninvasive methodology to measure Young's modulus (YM); however, the inhomogeneous nature of the liver organoid induces measurement uncertainty requiring a large number of indentations covering a wide scanning area. Here, we demonstrate that lipid-stained fluorescence imaging-assisted probe indentation significantly reduces the number of measurements by specifying the highly lipid-induced area.

Bacillus thuringiensis Bacteremia in a 30-Year-Old Intravenous Drug User: A Report of a Rare Case.

 is a gram-positive bacterium used in agriculture, with rare human infections that typically occur in immunocompromised individuals through environmental exposure. This report discusses the case of a 30-year-old intravenous drug user and polysubstance abuser who developed bacteremia due to . The patient originally presented with fever and leg ulcers from injection sites, and he was successfully treated with vancomycin.

Post-hoc analysis of the CARES trial suggests delayed progression of chronic kidney disease in patients with gout during urate-lowering therapy.

Based on the hypothesis that hyperuricemia is a modifiable risk factor for chronic kidney disease (CKD) progression, there is an expectation that urate-lowering therapy (ULT) could delay the progression of CKD. Here, we investigated changes in kidney function and the association of the serum uric acid (sUA) level and kidney function during ULT in patients with gout. To do this we conducted post-hoc analysis on patients who received ULT with either febuxostat or allopurinol for more than six months in the CARES trial.

3D-printed polycaprolactone/collagen/alginate scaffold incorporating phlorotannin for bone tissue regeneration: Assessment of sub-chronic toxicity.

The development of effective scaffolds for bone regeneration is crucial given the increasing demand for innovative solutions to address bone defects and enhance healing process. In this study, a polycaprolactone/fish collagen/alginate (P/FC/A) 3D scaffold incorporating phlorotannin was developed to promote bone tissue regeneration. While the efficacy of the P/FC/A scaffold has been demonstrated through in vitro and in vivo experiments, its sub-chronic toxicity in animal models remains understudied, raising concerns regarding its safety in clinical application.

Fusion Attention for Action Recognition: Integrating Sparse-Dense and Global Attention for Video Action Recognition.

Conventional approaches to video action recognition perform global attention over the entire video patches, which may be ineffective due to the temporal redundancy of video frames. Recent works on masked video modeling adopt a high-ratio tube masking and reconstruction strategy as a pre-training method to mitigate the problem of focusing on spatial features well but not on temporal features. Inspired by this pre-training method, we propose Fusion Attention for Action Recognition (FAR), which fuses the sparse-dense attention patterns specialized for temporal features with global attention during fine-tuning.

F NMR-Based Chiral Analysis of Organoboron Compounds via Chiral Recognition of Fluorine-Labeled Boronates with Cobalt Complexes.

This study aims to develop a method for the chiral analysis of organoboron compounds using nuclear magnetic resonance (NMR) spectroscopy. It addresses the longstanding challenge associated with these chiral organoboron compounds, which often require derivatization and pretreatment prior to chromatographic analysis. Our method utilizes tridentate ligands to facilitate effective ligand exchange and incorporates fluorine labels, allowing for the precise discrimination of F NMR signals.

Clindamycin-Loaded Polyhydroxyalkanoate Nanoparticles for the Treatment of Methicillin-Resistant Infected Wounds.

Owing to the growing resistance of methicillin-resistant (MRSA) to conventional antibiotics, the development of innovative therapeutic strategies for the treatment of MRSA-infected cutaneous wounds poses a significant challenge. Here, by using polyhydroxyalkanoates (PHA), emerging biodegradable and biocompatible polymers naturally produced by various microorganisms, we developed clindamycin-loaded PHA nanoparticles (Cly-PHA NPs) as a novel approach for the treatment of MRSA-infected cutaneous wounds. Cly-PHA NPs were characterized in terms of mean particle size (216.

Endemic Radiation of African Moonfish, (Gill 1863), in the Eastern Atlantic: Mitogenomic Characterization and Phylogenetic Implications of Carangids (Teleostei: Carangiformes).

This study offers an in-depth analysis of the mitochondrial genome of (Gill 1863), a species native to the Eastern Atlantic Ocean. The circular mitochondrial DNA molecule measures 16,541 base pairs and comprises 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, two ribosomal RNA genes, and a control region (CR). The nucleotide composition exhibits a notable adenine-thymine (AT) bias, accounting for 53.

Dynamic Reconstruction of Cu Catalyst Under Electrochemical NO Reduction to NH.

The electrochemical reduction of nitric oxide (NO) to ammonia (NH) offers a sustainable way of simultaneously treating the air pollutant and producing a useful chemical. Among catalyst candidates, Cu emerges as a stand-out choice for its superb NH selectivity and production rate. However, a comprehensive study concerning its catalytic behavior in the NO reduction environment is still lacking.

Evaluation of a mixture of livestock wastewater and food waste as a substrate in a continuous-flow microbial electrolysis cell.

While the efficiency of microbial electrolysis cell (MEC) systems has improved remarkably, their application in continuous reactors and wastewater treatment remains poorly understood. This study evaluated the performance of a continuous-flow MEC using livestock wastewater and food waste as substrates. The MEC system achieved a hydrogen production rate of 5.

Mitogenomic Architecture of Atlantic Emperor (Actinopterygii: Spariformes): Insights into the Lineage Diversification in Atlantic Ocean.

The evolutionary history of emperors, particularly in the Atlantic and Indo-West Pacific Oceans, remains largely unmapped. This study explores the maternal lineage evolution of Lethrinids by examining the complete mitogenome of , which is endemic to the Eastern Atlantic Ocean. Utilizing advanced next-generation sequencing, we found that the mitogenome spans 16,789 base pairs and encompasses 37 genes, including 13 protein-coding genes (PCGs), two ribosomal RNAs, 22 transfer RNAs, and an AT-rich control region (CR).

The impact of diagnosing provider type on longitudinal care for patients with newly diagnosed Huntington's disease.

Aims: This study evaluated the association between provider types for patients with newly diagnosed Huntington's disease (HD) and healthcare resource utilization (HCRU), costs, and treatment patterns.

Materials And Methods: This retrospective analysis used MarketScan databases (1 January 2017-31 December 2021) to identify provider types who diagnosed and managed US adult patients with HD. Patients with continuous enrollment 6 months pre- and 12 months post-diagnosis were included.

Habitat Loss in the IUCN Extent: Climate Change-Induced Threat on the Red Goral () in the Temperate Mountains of South Asia.

Climate change has severely impacted many species, causing rapid declines or extinctions within their essential ecological niches. This deterioration is expected to worsen, particularly in remote high-altitude regions like the Himalayas, which are home to diverse flora and fauna, including many mountainous ungulates. Unfortunately, many of these species lack adaptive strategies to cope with novel climatic conditions.

A photoelectrocatalytic system as a reaction platform for selective radical-radical coupling.

The selection of electrode material is a critical factor that determines the selectivity of electrochemical organic reactions. However, the fundamental principles governing this relationship are still largely unexplored. Herein, we demonstrate a photoelectrocatalytic (PEC) system as a promising reaction platform for the selective radical-radical coupling reaction owing to the inherent charge-transfer properties of photoelectrocatalysis.

Dynamically reconfigurable shape-morphing and tactile display via hydraulically coupled mergeable and splittable PVC gel actuator.

Shape-morphing displays alter their surface geometry to convey information through three-dimensional shapes. However, rapid transformation into seamless shapes with multimodal tactile sensations poses challenges. Here, we introduce a versatile soft shape-morphing and tactile display, using a novel actuator that combines a PVC gel composite, dielectric liquid, and an electrode array.