Publications by authors named "Hyun-Ji Ham"
The NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear. This study investigates NS1 binding protein's function in regulating stress granules during oxidative stress through interactions with GABARAP subfamily proteins.
View Article and Find Full Text PDFArticle Synopsis
- Snf7-3 is an essential part of the ESCRT pathway, crucial for endolysosomal functions and cognitive abilities.
- Knockout mice studies revealed that loss of Snf7-3 leads to social recognition issues and synaptic abnormalities, particularly in older and specifically targeted age groups.
- The findings emphasize that Snf7-3 is vital for normal cognitive and social behaviors, suggesting early synaptic disturbances can lead to significant cognitive deficits.
Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles. RNP granules contain RNA and numerous RNA-binding proteins, transiently formed through the liquid-liquid phase separation. The assembly or disassembly of numerous RNP granules is strongly controlled to maintain their homeostasis and perform their cellular functions properly.
View Article and Find Full Text PDF