Association of glutathione S-transferase M1 and T1 null/present polymorphism with physical performance in the Korean population.

Human physical performance is a highly complex phenotype that is influenced by various factors. In particular, genetic factors related to muscle fiber type, bone density, muscle performance, and metabolic processes are known to contribute in varying degrees to athlete status and physical performance in various ethnic groups. To investigate the relationship between these genetic factors and physical performances, we genotyped five genetic polymorphisms (ACE Ins/Del, ACTN3 R577X, ER-α C/T, GSTM1 null/present, and GSTT1 null/present) in 111 Korean athletes and 145 controls.

Does the Preoperative Varus Deformity Influence the Survival of Postoperative Neutral-Aligned TKAs? An Analysis With a Minimum 5-Year Follow-Up.

Background: Postoperative neutral alignment may be an important factor for longevity of total knee arthroplasty (TKA). In knees with severe varus deformity, greater soft tissue release and bone resection were required to achieve neutral alignment. We investigated the relationship between the severity of preoperative varus deformity and longevity of neutral-aligned TKAs.

Femoral Component Varus Malposition is Associated with Tibial Aseptic Loosening After TKA.

Background: The notion that neutral alignment is mandatory to assure long-term durability after TKA has been based mostly on short-film studies. However, this is challenged by recent long-film studies.

Questions/purposes: We conducted this long-film study to know (1) whether the risk of aseptic revision for nontraumatic reasons was greater among knees with greater than 3° varus or valgus (defined as "outliers") than those that were aligned within 3° of neutral on long-standing mechanical axis (hip to knee) radiographs; and (2) what the failure mechanisms were and whether the malalignment was femoral or tibial in origin, or both, among those in the outlier group.