Publications by authors named "Hyun-Bon Kang"
Endocrine-disrupting chemicals (EDCs), including phthalates, have been implicated in the development of non-alcoholic fatty liver disease (NAFLD) and hepatic fibrosis. This study investigates the age-dependent effects of butyl benzyl phthalate (BBP) exposure on lipid metabolism in the livers of young and aged mice. Young (2-month-old) and aged (20-month-old) male C57BL/6 mice were exposed to BBP through drinking water at a dose of 169 μg/kg/day for 6 and 4 months, respectively.
View Article and Find Full Text PDFDendritic cells (DCs) are specialized immune cells that play a crucial role in presenting antigens and activating cytotoxic T lymphocytes to combat tumors. The immune checkpoint receptor programmed cell death-1 (PD-1) can bind to its ligand programmed cell death-ligand 1 (PD-L1), which is expressed on the surface of cancer cells. This interaction suppresses T-cell activation and promotes immune tolerance.
View Article and Find Full Text PDFArticle Synopsis
- Head and neck squamous cell carcinoma (HNSCC) has poor survival rates and current treatments are highly toxic, creating a demand for new therapies that can effectively target cancer cells.
- The study explored the combination of radiotherapy, cetuximab, and expanded natural killer (NK) cells to enhance treatment efficacy, showing that radiation increases sensitivity of tumors to NK cells and cetuximab.
- Results revealed that this combination significantly suppressed cancer progression and improved survival, although adding PD-1 inhibitors did not provide extra benefit, indicating a promising new therapy for HNSCC.