The effect of metaphyseal holes and interposition material on the longitudinal growth stimulation of long bones in a rabbit model.

Aims: It remains unclear which factors influence overgrowth of the tibia, resulting from the metaphyseal hole created during anterior cruciate ligament (ACL) reconstruction in skeletally immature patients. This study aimed to investigate the effects of growth stimulation by creating a metaphyseal hole in a rabbit model, based on its distance from the physis and type of interposition material.

Methods: In Experiment 1, 38 skeletally immature male New Zealand white rabbits were randomized into one of four groups: a metaphyseal hole created at 5, 10, or 15 mm distal to the physis of the left proximal tibia with the hole filled with bone wax, or a sham control group.

Synthesis and Biological Evaluation of Peripheral 5HT Antagonists for Liver Fibrosis.

Liver fibrosis is characterized by an excessive accumulation of extracellular matrix components, leading to the distortion of liver architecture and function. Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT) stimulates the apoptosis of activated hepatic stellate cells and inhibits their proliferation while concurrently regressing hepatocyte proliferation. In this study, we present compound , which demonstrates promising efficacy both and .

Improving Electrochemical Performance of Ultrahigh-Loading Cathodes via the Addition of Multi-Walled Carbon Nanotubes.

Achieving high energy densities in lithium-ion batteries requires advancements in electrode materials and design. This study investigated the incorporation of multi-walled carbon nanotubes (MWCNTs) with high commercial viability as conductive additives into two types of high-nickel cathode materials, LiNiCoMnO and LiNiCoMnO. To ensure a uniform distribution within the electrodes, MWCNTs were uniformly dispersed in the solvent using ultrasonication, the most effective and straightforward dispersion method.

Ligand-Shell Cooperativity in a Bilayer Silica-Sandwiched Mixed-Metals Nanocatalyst Design for Absolute Selectivity Switch.

Unlike homogeneous metal complexes, achieving absolute control over reaction selectivity in heterogeneous catalysts remains a formidable challenge due to the unguided molecular adsorption/desorption on metal-surface sites. Conventional organic surface modifiers or ligands and rigid inorganic and metal-organic porous shells are not fully effective. Here, we introduce the concept of "ligand-porous shell cooperativity" to desirably reaction selectivity in heterogeneous catalysis.

Outcomes of Calcaneal Lengthening Osteotomy in Ambulatory Patients with Cerebral Palsy and Planovalgus Foot Deformity.

Background: To date, no studies have evaluated the longevity of calcaneal lengthening osteotomy (CLO) in patients with cerebral palsy (CP) and pes planovalgus. This study aimed to explore the changes in foot alignment following CLO in patients with CP, utilizing both radiographic evaluations and dynamic foot-pressure assessments.

Methods: A retrospective study of 282 feet in 180 ambulatory patients was performed.

Redox-Mediated Pyrene Electrolytes for Enhancing the Reversibility of Vertically Arranged Tin Electrodes in Seawater Batteries.

Seawater batteries (SWBs) have emerged as a next-generation battery technology that does not rely on lithium, a limited resource essential for lithium-ion batteries. Instead, SWBs utilize abundant sodium from seawater, offering a sustainable alternative to conventional battery technologies. Previous studies have demonstrated the feasibility of achieving high energy densities in SWB anodes using vertically aligned electrodes.

An Analysis of Components and Enhancement Strategies for Advancing Memristive Neural Networks.

Advancements in artificial intelligence (AI) and big data have highlighted the limitations of traditional von Neumann architectures, such as excessive power consumption and limited performance improvement with increasing parameter numbers. These challenges are significant for edge devices requiring higher energy and area efficiency. Recently, many reports on memristor-based neural networks (Mem-NN) using resistive switching memory have shown efficient computing performance with a low power requirement.

Identification of Bioactive Compounds from the Roots of and Their In Silico and In Vitro AMPK Activation Potential.

Libosch., which belongs to the Orobanchaceae family, is a perennial herb found in China, Japan, and Korea. In traditional medicine, it is used to cool the body, improve water metabolism in the kidney, and provide protection from metabolic diseases such as type 2 diabetes mellitus (T2DM) and obesity.

Identification of New Polyacetylenes from with PPAR-α Activity Study.

Leveille is a traditional medicine used to treat migraine headache and dysmenorrhea. In this study, three polyacetylenes, methyl (10,9,16)-16-acetoxy-9-hydroxyoctadeca-10,17-dien-12,14-diynoate (), methyl (10,9,16)-9,16-dihydroxyoctadeca-10-en-12,14-diynoate (), and methyl (10,9,16)-9,16-dihydroxyoctadeca-10,17-dien-12,14-diynoate (), were isolated from the aerial parts of . , together with seven known compounds (-).

Synthesis and Biological Evaluation of Peripheral HTR2A Antagonists for Colorectal Cancer.

Colorectal cancer is a prevalent and prominent contributor to global cancer-related fatalities with challenges in drug resistance and metastasis. Recent research highlights the potential relationship between serotonin and cancer. 5-Hydroxytryptamine receptor 2A (HTR2A) mRNA expression in colorectal cancer cells was found to be notably elevated compared to that in normal colon cells.

Antioxidant and Anti-Inflammatory Properties of Conceivable Compounds from Leaf Extract on RAW264.7 Cells.

Background/objectives: is a medicinal plant, but the scientific basis is still unclear. This study thoroughly investigated phenols from extract (GLE) to determine their potential as anti-inflammatory and antioxidant agents.

Methods: High-performance liquid chromatography (HPLC) and mass spectrometry (MS) were used to analyze the compounds in GLE.

Plasmon-Exciton Strong Coupling in Colloidal Au Nanocubes with Layered Molecular J-Aggregates.

Strong coupling between light and matter forms hybrid states, such as exciton-polaritons, which are crucial for advancements in quantum science and technology. Plasmonic metal nanoparticles, with their ultrasmall mode volumes, are effective for generating these states, but the coupling strength is often limited by surface saturation of excitonic materials. Additionally, cubic nanoparticles, which can generate strong local fields, have not been systematically explored.

Protective effect of gut microbiota restored by fecal microbiota transplantation in a sepsis model in juvenile mice.

Introduction: Restoring a balanced, healthy gut microbiota through fecal microbiota transplantation (FMT) has the potential to be a treatment option for sepsis, despite the current lack of evidence. This study aimed to investigate the effect of FMT on sepsis in relation to the gut microbiota through a sepsis model in juvenile mice.

Methods: Three-week-old male mice were divided into three groups: the antibiotic treatment (ABX), ABX-FMT, and control groups.

Vertebral Body Morphology in Neuromuscular Scoliosis with Spastic Quadriplegic Cerebral Palsy.

: The distorted vertebral body has been studied in scoliosis; however, there is little knowledge about the difference between neuromuscular and idiopathic scoliosis. This study aimed to investigate the vertebral body morphology in patients with spastic quadriplegic cerebral palsy and scoliosis (CP scoliosis) and compare them with those of apex- and Cobb angle-matched patients with adolescent idiopathic scoliosis (AIS). : Thirty-four patients with CP scoliosis and thirty-two patients with AIS were included.

Histopathologic findings of the lens capsule and persistent hyperplastic primary vitreous in Korean pediatric cataract patients.

This study aimed to measure lens capsule thickness and investigate histopathologic characteristics of persistent hyperplastic primary vitreous (PHPV) in Korean pediatric cataracts. We analyzed lens capsules from 116 eyes of 83 pediatric cataract patients treated between 2011 and 2015. The mean thickness of the anterior/posterior capsule was 7.

BEOL-Compatible 4F Oscillator Using Vertical InGaAs Biristor for Highly Scalable Monolithic 3D Ising Solver.

Ising solvers are important for efficiently addressing non-deterministic polynomial-time (NP)-hard combinatorial optimization problems (COPs), where scalability and compactness are crucial for practical applications. In this study, an experimental demonstration of an oscillator-based Ising solver employing a highly scalable 4F InGaAs bi-stable resistor (biristor) is presented. It is first explored the oscillation behavior of the InGaAs biristor, establishing that classical Ising spins can be emulated using the sub-harmonic injection locking (SHIL) technique.

Butanolides and clerodane diterpenes from the twigs of Casearia grewiifolia and their effects on adiponectin secretion.

Three butanolides derivatives, grewiifolides A-C, and nine clerodane diterpenes, grewiifolins M-U, as well as a known sterol were isolated from the twigs of Casearia grewiifolia. The chemical structures and configurations of all isolates were established by various spectroscopic means and chemical derivatization. In a cell-based phenotypic assay using the adipogenesis model of human bone marrow mesenchymal stem cells (hBM-MSCs), grewiifolide B significantly promoted adiponectin-secretion with EC value of 24.

Study of modulation in complex refractive indices induced by ultrafast relativistic electrons using infrared and THz probe pulses.

Achieving ultra-precise temporal resolution in ionizing radiation detection is essential, particularly in positron emission tomography, where precise timing enhances signal-to-noise ratios and may enable reconstruction-less imaging. A promising approach involves utilizing ultrafast modulation of the complex refractive index, where sending probe pulses to the detection crystals will result in changes in picoseconds (ps), and thus a sub-10 ps coincidence time resolution can be realized. Towards this goal, here, we aim to first measure the ps changes in probe pulses using an ionizing radiation source with high time resolutionWe used relativistic, ultrafast electrons to induce complex refractive index and use probe pulses in the near-infrared (800 nm) and terahertz (THz, 300m) regimes to test the hypothesized wavelength-squared increase in absorption coefficient in the Drude free-carrier absorption model.

A stochastic photo-responsive memristive neuron for an in-sensor visual system based on a restricted Boltzmann machine.

In-sensor computing has gained attention as a solution to overcome the von Neumann computing bottlenecks inherent in conventional sensory systems. This attention is due to the ability of sensor elements to directly extract meaningful information from external signals, thereby simplifying complex data. The advantage of in-sensor computing can be maximized with the sampling principle of a restricted Boltzmann machine (RBM) to extract significant features.