Background: Inspired concentrations of desflurane ≥ 1 minimum alveolar anesthetic concentration (MAC) have been related to sympathetic stimulation such as hypertension and tachycardia. The current study examined whether labetalol, an α(1) and β-adrenergic antagonist would blunt these hemodynamic responses.
Methods: Fifty-four ASA physical status I patients, aged 20-60 years, were enrolled in this study.