Despite the pandemic: upward trajectories of medication adherence and persistence in patients with dyslipidemia.

Background: Dyslipidemia, a major cardiovascular risk factor, requires consistent medication adherence, but new patients often struggle due to its asymptomatic nature. The COVID-19 pandemic has disrupted global healthcare. This study examined its impact on medication adherence and persistence among Korean patients with dyslipidemia (PWD), comparing the effects on new versus existing PWD.

A Machine Learning Risk Prediction Model for Gastric Cancer with SHapley Additive exPlanations.

Purpose: Gastric cancer (GC) prediction models hold potential for enhancing early detection by enabling the identification of high-risk individuals, facilitating personalized risk-based screening, and optimizing the allocation of healthcare resources.

Materials And Methods: In this study, we developed a machine learning-based GC prediction model utilizing data from the Korean National Health Insurance Service, encompassing 10,515,949 adults who had not been diagnosed with GC and underwent GC screening during 2013-2014, with a follow-up period of at least five years. The cohort was divided into training and test datasets at an 8:2 ratio, and class imbalance was mitigated through random oversampling.

Blood circulation effect of fermented citrus bioconversion product (FCBP) in EA.hy926 endothelial cells and high-fat diet-fed mouse model.

Background: The escalating global burden of cardiovascular diseases, largely driven by unhealthy lifestyle choices and dietary patterns, has intensified the search for effective and safe interventions. With current treatments often marred by significant side effects, the exploration of natural compounds such as flavonoids presents a compelling alternative.

Objective: This study investigated the effects of fermented citrus bioconversion product (FCBP), a fermented citrus bioflavonoid, on various markers of cardiovascular health in the context of a high-fat diet.

Fermented Gold Kiwi for Improved Gastric Health: Evaluation of Efficacy and Safety in a Randomised, Double-Blind, Placebo-Controlled Trial.

This randomised double-blind placebo-controlled trial evaluated the efficacy and safety of fermented gold kiwi (FGK) in improving gastrointestinal health. A total of 100 participants were enrolled and randomly assigned to treatment or placebo groups. Over 8 weeks, the participants consumed an FGK or placebo preparation daily.

Does the Sequence of Bimaxillary Orthognathic Surgery Affect Accuracy in Skeletal Class III Patients?

Background: It is necessary to determine whether the sequence of maxillary and mandibular surgeries in bimaxillary orthognathic surgery affects the accuracy of surgical outcomes.

Purpose: The study aimed to measure and compare the accuracy among patients who underwent maxilla-first versus mandible-first bimaxillary surgery to correct a class III skeletal pattern.

Study Design, Setting, Sample: This retrospective cohort study included consecutive patients treated by a single surgeon at one center using Le Fort I and bilateral sagittal split osteotomy surgery.

Association between endocrine-disrupting chemical mixtures and non-alcoholic fatty liver disease with metabolic syndrome as a mediator among adults: A population-based study in Korea.

Endocrine-disrupting chemicals (EDCs) may play a role in non-alcoholic fatty liver disease (NAFLD); however, studies on the combined effects of EDC mixtures on NAFLD development are limited. Here, we explored the association between exposure to EDC mixtures and NAFLD and investigated the potential mediating role of metabolic syndrome (MetS). We included participants from the Korean National Environmental Health Survey Cycle 4 (2018-2020) and quantified the urinary concentrations of various EDCs-eight phthalate metabolites, three phenols, one antibacterial compound, four parabens, four polycyclic aromatic hydrocarbons, and one pyrethroid pesticide metabolite-as well as serum concentrations of five perfluorinated compounds (PFCs).

Enhancing deep learning classification performance of tongue lesions in imbalanced data: mosaic-based soft labeling with curriculum learning.

Background: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of cancer of the oral cavity including the tongue. The early detection of oral cavity cancers and OPMDs is critical for reducing cancer-specific morbidity and mortality. Recently, there have been studies to apply the rapidly advancing technology of deep learning for diagnosing oral cavity cancer and OPMDs.

Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA: A Randomized, Double-Blind, Placebo Comparative Clinical Trial.

7-MEGA is a food product made from purified Alaska pollack fish oil containing palmitoleic acid (16:1), commonly referred to as omega-7. We sought to quantitatively evaluate whether this substance inhibits skin aging. A total of 101 middle-aged females were randomly allocated to the intervention ( = 50) or placebo group ( = 51).

Differential effects of digital media platforms on climate change risk information-sharing intention: A moderated mediation model.

This study analyzes the mechanisms through which risk messages about climate change lead to people's risk information-sharing intention, and how digital media platform type serves as a context that moderates those mechanisms. Our analysis is informed by the influence of presumed influence (IPI) model, and we adapt and expand that model in three ways. First, we apply the concept of perceived media reach to the context of digital media platforms, specifically news aggregators and social networking sites.

Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease.

X-linked inhibitor of apoptosis protein (XIAP) deficiency causes refractory inflammatory bowel disease. The XIAP protein plays a pivotal role in the pro-inflammatory response through the nucleotide-binding oligomerization domain-containing signaling pathway that is important in mucosal homeostasis. We analyzed the molecular mechanism of non-synonymous pathogenic variants (PVs) of XIAP BIR2 domain.

Hormone Replacement Therapy and Psoriasis Risk: A Nationwide Population-Based Cohort Study.

Background: Hormone replacement therapy (HRT) is used to relieve menopause symptoms, but has been reported to be associated with coronary heart disease and cancers in women. However, a link between HRT and psoriasis has yet to be established. The aim of this study was to determine the association between HRT and the risk of psoriasis.

Increased Risk of Renal Malignancy in Patients with Moderate to Severe Atopic Dermatitis.

Background: Evidence for an association between atopic dermatitis (AD) and cancer is still insufficient. In particular, the association between the risk of renal malignancy and the severity of AD has not been thoroughly investigated.

Objective: To investigate the risk of renal malignancy and determine the association between AD severity and cancer risk using data from the Korean National Health Insurance Service (KNHIS) database.

Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers.

Glioblastoma is one of the most malignant primary brain cancer. Despite surgical resection with modern technology followed by chemo-radiation therapy with temozolomide, resistance to the treatment and recurrence is common due to its aggressive and infiltrating nature of the tumor with high proliferation index. The median survival time of the patients with glioblastomas is less than 15 months.

Surgical management and final outcomes of chondrosarcoma of the temporomandibular joint: case series and comprehensive literature review.

Background: Surgical management for chondrosarcoma of the temporomandibular joint (TMJ) is challenging due to the anatomical location involving the facial nerve and the functional joint. The purpose of this case series was to analyze the largest number of TMJ chondrosarcoma cases reported from a single institution and to review the literature about chondrosarcoma involving the TMJ.

Methods: Ten TMJ chondrosarcoma patients at Seoul National University Dental Hospital were included in this study.

Glomerular filtration barrier modeling on a chip with tunable basement membrane deposition and 3D cultured podocytes.

investigation of a glomerular filtration barrier (GFB) remains difficult because of the inability to mimic its specialized structure, although various kidney diseases are characterized by GFB dysfunction. Here, the development of a microfluidic model that replicates the physiology of the GFB has been achieved by tunable glomerular basement membrane (gBM) deposition and 3D co-culture of podocytes with glomerular endothelial cells (gECs). By precisely controlling the thickness of the gBM, our model successfully reproduced the biphasic response of the GFB, where variations in gBM thickness influence barrier properties.

Effect of maxillary impaction on mandibular surgical accuracy in virtually-planned orthognathic surgery: A retrospective study.

Although surgical accuracy has been evaluated in bi-maxillary procedures, few studies have investigated the relationship between maxillary and mandibular accuracy. The present study evaluated the effect of maxillary impaction accuracy on mandibular surgical outcome. This cohort study analyzed skeletal class III patients who underwent planned maxillary impaction in bi-maxillary surgery.

The Role of Social Presence in Relationships Among Gender Stereotypes, Sexism, and In-Game Sexual Harassment Among Young Korean Gamers.

Despite the rapidly increasing number of female gamers worldwide, female players are still experiencing discrimination, stereotyping, and objectification in digital games. The present study examined the relationships among gender stereotypes, sexism, and sexual harassment in online games, and further investigated how enhanced social presence contributes to intensifying the effects of gender stereotypes and sexism on sexual harassment. An online survey was conducted among 521 young male Korean gamers who regularly play two genres of online games: role-playing games and first-person shooter games.

Self-optimization of training dataset improves forecasting of cyanobacterial bloom by machine learning.

Data-driven model (DDM) prediction of aquatic ecological responses, such as cyanobacterial harmful algal blooms (CyanoHABs), is critically influenced by the choice of training dataset. However, a systematic method to choose the optimal training dataset considering data history has not yet been developed. Providing a comprehensive procedure with self-based optimal training dataset-selecting algorithm would self-improve the DDM performance.

Schisandrin B protects boar spermatozoa against oxidative damage and increases their fertilization ability during in vitro storage.

Oxidative stress due to low temperatures during in vitro preservation reduces boar spermatozoa quality. It has been proven that Schisandrin B (Sch-B) can act against oxidative stress in cells. Therefore, the purpose of this study was to investigate whether the treatment with Sch-B could improve the quality of boar sperm during storage at 17 °C.