Publications by authors named "Hyun Chul Youn"
Article Synopsis
- - This study investigated the link between delirium and dementia in a large group of hospitalized patients over 60 years old, using data from over 11 million electronic health records in South Korea.
- - After matching groups of patients with and without delirium, the results showed that those with delirium had a significantly higher risk of developing various forms of dementia, with hazard ratios indicating increased risks for Alzheimer's and vascular dementia.
- - The findings emphasize the critical need for early detection and treatment of delirium to potentially prevent dementia, suggesting further research is necessary to understand the relationship between the two conditions.
Objective: This study was performed to evaluate the efficacy and safety of lurasidone (160 mg/day) compared to quetiapine XR (QXR; 600 mg/day) in the treatment of acutely psychotic patients with schizophrenia.
Methods: Patients were randomly assigned to 6 weeks of double-blind treatment with lurasidone 160 mg/day (n=105) or QXR 600 mg/day (n=105). Primary efficacy measure was the change from baseline to week 6 in Positive and Negative Syndrome Scale (PANSS) total score and Clinical Global Impressions severity (CGI-S) score.
Article Synopsis
- The study analyzed 10-year trends of electroconvulsive therapy (ECT) usage in South Korea using health insurance data from 2008 to 2018, focusing on patient demographics and clinical characteristics.
- The findings showed a significant increase (240.49%) in ECT prevalence, especially among younger and older patients, with a higher proportion of female patients and a rising number of those with affective disorders.
- The results suggest that while ECT usage is growing, its prevalence in South Korea remains lower than in other countries, potentially due to mental health stigma and insufficient awareness, highlighting the need for broader ECT adoption given the country's high suicide rates.*
Objective: This study aims to investigate the thoughts of the general population regarding life-sustaining treatment for both oneself and family members and to assess the factors associated with those thoughts.
Methods: A total of 1,500 individuals participated in this study by completing a questionnaire consisting of self-reporting items with some instructions, basic demographic information, thoughts on life-sustaining treatment, and psychosocial scales. The disease status was calculated using the Charlson Comorbidity Index.
Objective: Successful transition to school is of great importance to children with autism spectrum disorder (ASD). The purpose of this study was to develop a school readiness inventory for Korean children with ASD, and demonstrate its content validity and reliability.
Methods: The Korean School Readiness Inventory (K-SRI) was developed to assess current levels of some fundamental skills needed for attending school for children with ASD.
Factors Affecting Stress and Mental Health During the COVID-19 Pandemic.
Psychiatry Investig
February 2023
Objective: This study examined the factors influencing the mental health and stress of individuals during the coronavirus disease-2019 (COVID-19) pandemic.
Methods: A total of 600 participants were enrolled in this anonymous questionnaire survey that included questions on their demographic profiles and experiences related to the COVID-19 pandemic. The COVID-19 Stress Scale for Korean People (CSSK), Warwick- Edinburgh Mental Wellbeing Scale, Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Insomnia Severity Index, and Multidimensional Scale of Perceived Social Support were used.
Objective: To investigate the effects of long-acting injectable 3-monthly paliperidone palmitate on the clinical and social functioning of patients with schizophrenia.
Methods: This study enrolled patients with schizophrenia receiving long-acting injectable 1-monthly paliperidone palmitate for at least 4 months and who subsequently received 3-monthly paliperidone palmitate. Accordingly, 418 patients were followed up for 24 weeks.
Introduction: To investigate the efficacy of autologous serum gel in patients with lagophthalmos combined with neurotrophic persistent corneal epithelial defects (PEDs).
Methods: This is retrospective, case-series study enrolled 15 patients with lagophthalmos complicated by neurotrophic PEDs refractory to medical treatment including autologous serum eye drops. They were treated with autologous serum gel in conjunction with conservative treatment.
Background: Non-adherence in patients with bipolar disorder (BD) results in symptoms, such as aggravation, BD recurrence, emergency room visits, re-hospitalization, and poor psychosocial outcomes. Though non-adherence rates have been reported to range between 30-50% in patients with BD, the problem of adherence is often either overlooked by the physician or denied by the patient. An essential first step to enhancing medication adherence is to objectively estimate adherence.
View Article and Find Full Text PDFMethods: A retrospective review of was conducted of patients who received modified epiblepharon repair preserving orbicularis oculi muscle from April 2016 to October 2018. Removal of the orbicularis oculi muscle was minimally performed with eyelash rotating sutures and epicanthal weakening procedure. The preoperative severity of epiblepharon was classified according to skin fold height and cilia-corneal touch.
View Article and Find Full Text PDFObjective: Subjective reports of patients with insomnia often show a discrepancy with their objective assessments of sleep. We aimed to assess subjective-objective sleep discrepancy in subjects with insomnia disorder as well as the psychological factors associated with the discrepancy.
Methods: This study is a secondary analysis of the baseline data of a randomized controlled study on 110 adults aged 18 years to 59 years with insomnia disorder.
Objective: Young adults putting off marriage and having less children have become recent trends in many modern societies. Yet less is known about the psychological factors underlying the drastically low marriage and fertility rates. We hypothesized that childhood maltreatment experience may have a negative association with one's marriage and childbearing intention.
View Article and Find Full Text PDFDecreased Cortical Thickness and Local Gyrification in Individuals with Subjective Cognitive Impairment.
Clin Psychopharmacol Neurosci
November 2021
Objective: Subjective cognitive impairment (SCI) is associated with future cognitive decline. This study aimed to compare cortical thickness and local gyrification index (LGI) between individuals with SCI and normal control (NC) subjects.
Methods: Forty-seven participants (27 SCI and 20 NC) were recruited.
Co-occurring depression and mild cognitive impairment (MCI) in older adults are important because they have a high risk of conversion to dementia. In the present study, task-related F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) was used to analyse older adults with concomitant depression and MCI. We recruited 20 older adults with simultaneous depression and MCI and 10 older adults with normal cognition (NC).
View Article and Find Full Text PDFBackground: This study aimed to investigate the 1-year changes in neuropsychological test results in older adults with concomitant late-life depression (LLD) and mild cognitive impairment (MCI) according to the presence or absence of brain amyloidopathy.
Methods: All subjects underwent F-florbetaben-positron emission tomography and a standardized neuropsychological battery. The subjects were divided based on brain amyloidopathy and severity of depressive symptoms into the following groups: LLD-MCI-A(+), subthreshold depression (STD)-MCI-A(+), major depressive disorder (MDD)-MCI-A(+), LLD-MCI-A(-), STD-MCI-A(-), and MDD-MCI-A(-).
Background: Amyloid positron emission tomography (PET) makes it possible to diagnose Alzheimer's disease (AD) in its prodromal phase including mild cognitive impairment (MCI). This study evaluated the cost-effectiveness of including amyloid-PET for assessing individuals with MCI.
Methods: The target population was 60-year-old patients who were diagnosed with MCI.
Article Synopsis
- - This study examined the effects of combining memantine with acetylcholinesterase inhibitors (AchEIs) on behavioral symptoms in patients with moderate Alzheimer's dementia (AD) compared to using AchEIs alone.
- - Conducted over 12 weeks with 148 participants, the study measured various symptoms using different assessment scales, showing the combination therapy led to greater improvement in disinhibition symptoms.
- - The results suggest that adding memantine could be helpful for patients showing disinhibition symptoms, but more research is needed to confirm these findings and evaluate the overall benefits of this combination therapy.
Late-life depression (LLD) may increase the risk of Alzheimer's dementia (AD). While amyloidopathy accelerates AD progression, its role in such patients has not yet been elucidated. We hypothesized that cerebral amyloidopathy distinctly affects the alteration of brain network topology and may be associated with distinct cognitive symptoms.
View Article and Find Full Text PDFArticle Synopsis
- The study explores Koreans’ attitudes toward life-sustaining treatments, revealing that more individuals prefer not to receive such treatments in terminal illness situations.
- Participants were surveyed in a Guro-gu dementia center, and results showed that those opting out often cited physical and mental distress as key factors influencing their decision.
- Psychological assessments indicated that those who opted out had higher anxiety and depression levels, alongside lower social support from family, highlighting the emotional complexities surrounding end-of-life choices.
Background: Elderly patients with late-life depression (LLD) often report mild cognitive impairment (MCI), so Alzheimer's disease (AD) is hard to identify in these patients. We aimed to identify the structural and functional differences between prodromal AD and LLD-related MCI.
Methods: We performed voxel-based morphometry and functional connectivity (FC) analyses in elderly patients with both LLD and MCI to compare alterations between those with cerebral amyloidopathy and those without.
Objectives: To investigate the presence of cerebral amyloidopathy and its associations with performances on neurocognitive tests and clinical features in depressed elders with mild cognitive impairment (MCI).
Methods/design: In total, 94 older adults with concomitant MCI and some depressive symptoms were included in this study. Cerebral amyloidopathy was evaluated using F-florbetaben-positron emission tomography.
Several metrics of analysis of magnetic resonance imaging (MRI) have been used to assess Alzheimer's disease (AD)-related neurodegeneration. We compared four structural brain MRI analysis metrics, cortical thickness, volume, surface area, and local gyrification index (LGI), in different stages of AD-related cognitive decline. Participants with normal cognition, mild cognitive impairment, and AD were included (34 participants per group).
View Article and Find Full Text PDFPurpose: Some elders with subjective cognitive deficits (SCD) develop prodromal phase of dementia over time; however, little is known about how they differ from those with normal cognition (NC). Thus, we aim to distinguish the differences in the brain network of elders with SCD and NC.
Methods: Multiple diffusion-weighted images (DWI) and T1-weighted images were obtained from 18 subjects with NC and 26 subjects with SCD.