Ascofuranone inhibits epidermal growth factor-induced cell migration by blocking epithelial-mesenchymal transition in lung cancer cells.

Ascofuranone, an isoprenoid antibiotic initially purified from a culture broth of Ascochyta viciae, has multiple anticancer effects. However, the impacts of ascofuranone on the epithelial-mesenchymal transition (EMT) and epidermal growth factor (EGF)-induced effects on human lung cancer cell lines have not been previously reported. Here, we show that ascofuranone exerts its anticancer effects by inhibiting the EGF-induced EMT and cell migration in human lung cancer cell lines.

Virtual stenting of intracranial aneurysms: application of hemodynamic modification analysis.

Background: Practical application of hemodynamic modification analysis based on computational fluid dynamics (CFD) in intracranial aneurysms is still under study.

Purpose: To determine the clinical applicability of virtual stenting of aneurysms by comparing the simulated results with clinical outcome of real stenting.

Material And Methods: Three-dimensional (3D) digital subtraction angiography (DSA) images were imported to a dedicated integrated prototypic CFD platform (Siemens Healthcare GmbH) which allows all necessary steps of 3D models for CFD analysis.