Publications by authors named "Hyoree Park"
Article Synopsis
- Critical COVID-19 cases show heightened eosinophil-mediated inflammation compared to non-critical cases, suggesting a significant role of these immune cells in severe disease.* -
- There is an increase in Th2-biased adaptive immune responses and complement activation in severe COVID-19, indicating a more intense immune reaction in critical patients.* -
- The formation of immune complexes and membrane attack complexes in the lungs of severe cases points to how enhanced antibody responses and complement activation contribute to disease severity in COVID-19.*
Background/aims: Coronavirus disease 2019 (COVID-19) is associated with acute respiratory syndrome. The mechanisms underlying the different degrees of pneumonia severity in patients with COVID-19 remain elusive. This study provides evidence that COVID-19 is associated with eosinophil-mediated inflammation.
View Article and Find Full Text PDFObjectives: We aimed to assess the longevity of spike-specific antibody responses and neutralizing activity in the plasma of recovered Middle East respiratory syndrome (MERS) patients.
Methods: We traced the antibody responses and neutralizing activity against MERS coronavirus (MERS-CoV) in peripheral blood samples collected from 70 recovered MERS patients for 5 years after the 2015 MERS outbreak in South Korea. We also measured the half-life of neutralizing antibody titres in the longitudinal specimens.
Background: Zoonotic coronaviruses have emerged as a global threat by causing fatal respiratory infections. Given the lack of specific antiviral therapies, application of human convalescent plasma retaining neutralizing activity could be a viable therapeutic option that can bridges this gap.
Methods: We traced antibody responses and memory B cells in peripheral blood collected from 70 recovered Middle East respiratory syndrome coronavirus (MERS-CoV) patients for 3 years after the 2015 outbreak in South Korea.