Publications by authors named "Hyojin Park"

The integrity of the blood-retina barrier (BRB) is crucial for phototransduction and vision, by tightly restricting transport of molecules between the blood and surrounding neuronal cells. Breakdown of the BRB leads to the development of retinal diseases. Here, we show that Netrin-1/Unc5b and Norrin/Lrp5 signaling establish a zonated endothelial cell gene expression program that controls BRB integrity.

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Purpose: This study aimed to provide a deeper understanding of the response status and school nurses' experience of the prolonged COVID-19 pandemic in Korea.

Method: Recognizing the limitations of existing tools in capturing prolonged COVID-19 response, we divided the COVID-19 pandemic into different wave periods and adopted a mixed-methods design enrolling school nurses in elementary, middle, and high schools in Korea to gain a comprehensive view. A quantitative survey was conducted among 153 school nurses nationwide and in-depth interviews were conducted with nine, using Van Kaam's phenomenological analysis.

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Postoperative ileus (POI) is a delay in gastrointestinal transit following surgery that leads to various complications. There is limited understanding of its effective treatment options. CKD-495 and eupacidin are natural products licensed for treating mucosal lesions in acute and chronic gastritis; however, little is known about their effects on intestinal permeability.

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Porcine oocytes undergo maturation (IVM) for 42-44 h. During this period, most oocytes proceed to metaphase and then to pro-metaphase if the nucleus has sufficiently matured. Forty-four hours is sufficient for oocyte nuclear maturation but not for full maturation of the oocyte cytoplasm.

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This study aimed to examine how concurrent working memory (WM) loads affect selective attention, and to explore developmental differences between young adults and children/adolescents aged 10 to 14 years. : We employed a modified Stroop task with verbal or spatial WM loads to assess their impact on attention. In adults, we found increased Stroop effects when WM load overlapped with target processing and decreased Stroop effects when WM load overlapped with distractor processing.

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Article Synopsis
  • The study investigated how probiotics can help improve postoperative ileus (POI) by examining factors like intestinal permeability, inflammation, and tight junction protein expression in guinea pigs.
  • Guinea pigs undergoing surgery were divided into three groups: control, POI, and probiotic, with the probiotic group receiving treatment before surgery; results showed probiotics helped reduce inflammation and restore essential proteins in the intestines.
  • Ultimately, the findings suggest that probiotics could be a beneficial treatment option for managing POI by enhancing gut health and reducing inflammatory responses.
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Decoding human speech requires the brain to segment the incoming acoustic signal into meaningful linguistic units, ranging from syllables and words to phrases. Integrating these linguistic constituents into a coherent percept sets the root of compositional meaning and hence understanding. One important cue for segmentation in natural speech is prosodic cues, such as pauses, but their interplay with higher-level linguistic processing is still unknown.

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Achieving an optimal balance between strength and ductility in advanced engineering materials has long been a challenge for researchers. In the field of material strengthening, most approaches that prevent or impede the motion of dislocations involve ductility reduction. In the present study, we propose a strengthening approach based on spinodal decomposition in which Cu and Al are introduced into a ferrous medium-entropy alloy.

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Transmembrane protein 135 (TMEM135) is a 52 kDa protein with five predicted transmembrane domains that is highly conserved across species. Previous studies have shown that TMEM135 is involved in mitochondrial dynamics, thermogenesis, and lipid metabolism in multiple tissues; however, its role in the inner ear or the auditory system is unknown. We investigated the function of TMEM135 in hearing using wild-type (WT) and ( ) mutant mice on a CBA/CaJ background, a normal-hearing mouse strain.

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  • - Eosinophilic esophagitis (EoE) is classified into two types based on endoscopic findings: inflammatory and fibrostenotic, and its connection to immunoglobulin G4 (IgG4) antibodies is being explored.
  • - A study compared 19 EoE patients with 12 non-obstructive dysphagia (NOD) controls, analyzing IgG4 and eosinophil cell counts in endoscopic samples, which showed significantly higher counts in the EoE group.
  • - Results indicated that IgG4 levels varied among EoE's endoscopic phenotypes, with the combined phenotype showing the highest levels, highlighting the need for further research and emphasizing the importance of both
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The cytotoxic mycotoxin deoxynivalenol (DON) reportedly has adverse effects on oocyte maturation and embryonic development in pigs. Recently, the interplay between cell apoptosis and endoplasmic reticulum (ER) stress has garnered increasing attention in embryogenesis. However, the involvement of the inositol-requiring enzyme 1 (IRE1)/c-jun N-terminal kinase (JNK)/C/EBP homologous protein (CHOP) pathways of unfolded protein response (UPR) signaling in DON-induced apoptosis in porcine embryos remains unknown.

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The development and commercialization of digital therapeutics are increasing. The aim of this study was to determine the effects of digital technology interventions on cognitive function, thereby providing evidence for the development and practical application of interventions to manage cognitive function in patients with mild cognitive impairment and dementia. We conducted a systematic review and meta-analysis of randomized controlled trials according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines.

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The Indian Ocean Dipole (IOD) is a major climate variability mode that substantially influences weather extremes and climate patterns worldwide. However, the response of IOD variability to anthropogenic global warming remains highly uncertain. The latest IPCC Sixth Assessment Report concluded that human influences on IOD variability are not robustly detected in observations and twenty-first century climate-model projections.

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  • Achalasia is an esophageal disorder causing swallowing difficulties and chest pain, and this study investigated the link between autonomic nervous system (ANS) dysfunction and achalasia symptoms in patients.
  • In a study of 19 achalasia patients and 10 healthy controls, a higher percentage of achalasia patients (69%) reported ANS dysfunction symptoms compared to controls (30%); the symptoms' severity was significantly greater in the patient group.
  • The findings indicated that female achalasia patients and those with ANS dysfunction symptoms exhibited elevated cardiac activity, suggesting a need for closer monitoring of cardiac health in these individuals.
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Ochratoxin A (OTA), a mycotoxin found in foods, has a deleterious effect on female reproduction owing to its endocrine-disrupting activity mediated through endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) production. However, the mechanisms of OTA-induced ER stress in pig embryos during in vitro culture (IVC) are not yet fully understood. In the present study, porcine embryos were cultured for two days in an IVC medium supplemented with 0.

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Visual speech plays a powerful role in facilitating auditory speech processing and has been a publicly noticed topic with the wide usage of face masks during the COVID-19 pandemic. In a previous magnetoencephalography study, we showed that occluding the mouth area significantly impairs neural speech tracking. To rule out the possibility that this deterioration is because of degraded sound quality, in the present follow-up study, we presented participants with audiovisual (AV) and audio-only (A) speech.

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Memory allocation, which determines where memories are stored in specific neurons or synapses, has consistently been demonstrated to occur via specific mechanisms. Neuronal allocation studies have focused on the activated population of neurons and have shown that increased excitability via cAMP response element-binding protein (CREB) induces a bias toward memoryencoding neurons. Synaptic allocation suggests that synaptic tagging enables memory to be mediated through different synaptic strengthening mechanisms, even within a single neuron.

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Despite recent advancements in identifying engram cells, our understanding of their regulatory and functional mechanisms remains in its infancy. To provide mechanistic insight into engram cell functioning, we introduced a novel local microcircuit labeling technique that enables the labeling of intraregional synaptic connections. Utilizing this approach, we discovered a unique population of somatostatin (SOM) interneurons in the mouse basolateral amygdala (BLA).

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  • The research presents the successful stereoselective total synthesis of dechlorotrichotoxin A from the natural monoterpenoid (-)-citronellal, as well as a synthesis of a trichotoxin A mixture.! -
  • Key synthetic steps included the introduction of three alkenes and the formation of a stereogenic secondary alcohol, utilizing techniques like olefin cross-metathesis, Tebbe olefination, and enantioselective allylation with chiral phosphoric acid.! -
  • The synthesized dechlorotrichotoxin A's spectroscopic data was compared to existing reports, confirming that the isolated polyketide pertains to trichotoxin A, not dechlorotrich
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Background: Trastuzumab is the only approved target agent for the first-line treatment of human epidermal growth factor receptor-2 (HER-2) positive gastric cancer; however, trastuzumab resistance is a major problem in clinical practice. To comprehend the mechanism of trastuzumab resistance, we focused on the Wnt/β-catenin signaling pathway and its influence on the phenotypes and behavior of trastuzumab-resistant gastric cancer cells.

Methods: Trastuzumab-resistant NCI-N87R cells were established in vitro from the human gastric cancer cell line NCI-N87 by dose-escalating repeated trastuzumab treatment.

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Heparan sulfate (HS) plays a critical role in various biological processes as a vital component of the extracellular matrix. In this study, we synthesized three fluorescent probes (1-3) comprising Arg-rich peptides as HS receptors and a fluorophore capable of exhibiting red-shifted emissions upon aggregation. All three probes demonstrated ratiometric responses to HS and heparin in aqueous solutions.

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Objective: Immune-mediated inflammatory disease (IMID) is associated with an increased risk of mortality. It is unclear whether the higher mortality is attributable to the IMIDs themselves or to the higher prevalence of comorbidities in IMIDs. We aimed to investigate whether IMIDs confer a higher risk of mortality.

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Ceramide induces autophagy upon starvation via downregulation of nutrient transporters. To elucidate the mechanism by which starvation regulates autophagy in mouse embryos, the present study investigated nutrient transporter expression and the effect of C2-ceramide on in vitro embryo development, apoptosis, and autophagy. The transcript levels of the glucose transporters Glut1 and Glut3 were high at the 1- and 2-cell stages, and gradually decreased at the morula and blastocyst (BL) stages.

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