Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation in rats.

Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively exposed to CCl. Serum chemistry showed that AITC (doses of 5 and 50 mg) administered to rats exposed to CCl significantly reduced the levels of alanine aminotransferase and aspartate aminotransferase activity that were elevated in CCl-intoxicated rats.

Hepatoprotective effects of allyl isothiocyanate against carbon tetrachloride-induced hepatotoxicity in rat.

We evaluated the hepatoprotective activity of allyl isothiocyanate (AITC) against carbon tetrachloride (CCl4)-induced liver injury in rats. Sprague Dawley rats were orally administered AITC at doses of 5 (AITC 5) and 50 (AITC 50) mg/kg body weight once daily for 3 days, with or without intraperitoneal injection of CCl4. Serum chemistry was assessed for changes in alanine aminotransferase (ALT) and aspartate aminotransferase (AST).

Effects of Kudoa septempunctata genotype ST3 isolate from Korea on ddY suckling mice.

This study investigated the effects of Kudoa septempunctata genotype ST3 spores on ddY suckling mice. Purified Kudoa septempunctata spores were administered into the stomachs of the mice at 5 × 10(6) or 5 × 10(7) spores/mouse, with inactivated Kudoa (5 × 10(6) spores/mouse) or vehicle as controls. No abnormal clinical symptoms were observed and there were no variations in fluid accumulation ratio and cytokine gene expression in all groups.

Histochemical study of the olfactory mucosae of the horse.

The olfactory mucosae of the horse were examined by using histology and lectin histochemistry to characterize the carbohydrate sugar residues therein. Histological findings revealed that olfactory epithelium (OE) consisted of both olfactory marker protein (OMP)- and protein gene product (PGP) 9.5-positive receptor cells, supporting cells and basal cells with intervening secretory ducts from Bowman's glands.