Publications by authors named "Hyojin An"
Background: Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disorder with a complex etiology. Despite its increasing prevalence, treatment of AD is still limited. Indole-3-carbinol (I3C) is found in cruciferous vegetables and is formed when these vegetables are cut, chewed, or cooked; it exerts diverse pharmacological activities.
View Article and Find Full Text PDFcontains valuable bioactive compounds, including astaxanthin, proteins, and fatty acids. Astaxanthin is known for its various health benefits, such as preserving the redox balance and reducing inflammation. However, its low stability and poor water solubility present challenges for various applications.
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- Atopic dermatitis is a chronic skin condition marked by itching and eczema, prompting research into new treatments influenced by environmental factors.
- This study explored compounds from a specific plant to find potential treatments for atopic dermatitis, identifying eleven compounds, including two polyacetylenes and a benzoic acid derivative.
- Among these, astersaponin J showed promise by significantly lowering inflammatory cytokines in skin cells, suggesting that these compounds could help mitigate the immune response linked to atopic dermatitis.
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- Bunge (AA), a plant from the Liliaceae family, has traditional uses for managing inflammation, but its effects on atopic dermatitis (AD) were previously unexplored.
- The study showed that topical AA ointment significantly reduced AD symptoms in mice and keratinocytes by improving skin conditions and reducing inflammation markers.
- AA works by lowering levels of certain cytokines and signaling molecules involved in skin inflammation, suggesting it could be a promising treatment for atopic dermatitis.
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- Microbial fermentation is key for producing essential goods sustainably, with a focus on amino acid production from engineered organisms.
- This study tested the safety of biomass products from bioengineered microorganisms using the AMES test and oral toxicity test in rats, finding no harmful effects at the doses tested.
- The results support the potential use of these biomass products as safe feed materials, emphasizing the need for thorough safety assessments and adherence to regulatory standards in biotechnological applications.
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- Papain (PN) is a proteolytic enzyme with potential anti-inflammatory properties, which this study investigates in relation to atopic dermatitis (AD) induced by house dust mites in mice and human skin cells.
- The study found that oral intake of PN reduced skin inflammation, lowered transepidermal water loss (TEWL), and decreased inflammatory markers in AD mice, indicating its effectiveness in alleviating AD symptoms.
- Mechanistically, PN appears to inhibit key signaling pathways (MAPKs and STAT) involved in inflammation, while also improving cell survival and enhancing antioxidant defenses in damaged skin cells.
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- Obesity increases the risk of cardiovascular disease, and a modified herbal formula called Gambi-jung (GBJ) shows promise in inducing weight loss in obese mice fed a high-fat diet (HFD).
- The study investigated the effects of GBJ and its primary herb, Stapf (ES), on cardiac apoptosis due to HFD, using various analysis techniques which revealed that GBJ significantly reversed apoptosis-related protein changes in the heart compared to ES.
- Long-term administration of GBJ was found to improve mitochondrial function and did not show adverse effects on heart tissue, supporting its potential effectiveness in preventing cardiac cell apoptosis linked to obesity.
Article Synopsis
- * In experiments with rats, HemoHIM G showed no signs of acute toxicity even at high doses (up to 5000 mg/kg/day) and did not lead to any adverse effects after 13 weeks of repeated dosing.
- * Tests conducted for potential genotoxicity confirmed that HemoHIM G is non-mutagenic and non-clastogenic, indicating it is safe for use as a food ingredient.
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- The study explores the effects of Magnolia Cortex (MO) on obesity and its mechanisms, building on previous research linking MO to lipid metabolism.
- Analysis highlighted that MO extract contains compounds Honokiol and Magnolol, which play a role in reducing lipid accumulation in fat cells.
- Results showed that MO treatment boosted protein expression of SIRT1 and AMPK, leading to improved fat processing and reduced fatty liver in obese mice, suggesting MO could be beneficial for obesity management.
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- * Sipyimigwanjung-tang (SGT), a traditional herbal remedy, has been used historically to address conditions associated with obesity, such as edema and jaundice.
- * In a study with high-fat diet-induced obese mice, SGT significantly reduced weight gain, adipocyte size, and liver lipid accumulation, suggesting it may have promising anti-obesity effects.
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- * Myrocin A demonstrated antiproliferative effects on BPH-1 and dihydrotestosterone-stimulated WPMY-1 cells, suggesting potential therapeutic benefits against benign prostatic hyperplasia (BPH) in middle-aged and elderly men.
- * Treatment with myrocin A led to significant suppression of mRNA levels related to the androgen receptor and its activity, indicating a reduction in pathways associated with prostatic cell proliferation and BPH progression.
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- * The study investigates whether combining cabbage with chestnut honey or a modified version rich in kynurenic acid can enhance both taste and health benefits for treating gastric issues.
- * Findings reveal that these combinations reduce inflammation and protect the stomach lining by promoting antioxidant activity and regulating specific inflammatory pathways in cells and rat models.
Tight junction (TJ) proteins (Tjps), Tjp1 and Tjp2, are tight junction-associated scaffold proteins that bind to the transmembrane proteins of tight junctions and the underlying cytoskeleton. In this study, we first analyzed the tumorigenic characteristics of B16-F10 melanoma cells, including cell proliferation, migration, invasion, metastatic potential, and the expression patterns of related proteins, after the CRISPR-Cas9-mediated knockout (KO) of genes. The proliferation of and KO cells significantly increased in vitro.
View Article and Find Full Text PDFAccelerated Oral Healing by Nakai from Hot Melt Extrusion Technology: An In Vitro Study.
Medicina (Kaunas)
November 2023
Article Synopsis
- - This study investigates how Nakai (AG) prepared by hot-melt extrusion (AGH) influences oral wound healing, focusing on human gingival fibroblast (HGF) cells.
- - Results show that AGH significantly reduces nitric oxide production when inflammation is induced and enhances cell proliferation and migration compared to AG and control groups.
- - AGH also boosts the expression of key wound healing markers like VEGF and COL1α1, indicating its potential to accelerate oral wound healing in laboratory settings.
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- Drynaria rhizome is a herbal remedy from East Asia known for its bone-strengthening properties, but its effects on obesity and bone health are complex due to the role of visceral fat in osteoporosis.
- A study on high-fat diet-induced obese mice showed that supplementation with Drynaria rhizome extract (DRE) led to weight loss without affecting food intake.
- DRE improved lipid metabolism by regulating key transcription factors and decreasing fat accumulation in the liver and fat pads, suggesting it could be a beneficial natural product for both bone health and obesity management.
Human endogenous retrovirus (HERV)-K was reportedly inserted into the human genome millions of years ago and is closely related to various diseases, including cancer and immune regulation. In our previous studies, CRISPR-Cas9-enabled knockout (KO) of the HERV-K gene was found to potentially reduce cell proliferation, cell migration, and invasion in colorectal and ovarian cancer cell lines. The immune response involves the migration and invasion of cells and is similar to cancer; however, in certain ways, it is completely unlike cancer.
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- * The study investigates Magnoliae flos, a flower bud extract, for its potential to treat atopic dermatitis by suppressing inflammatory pathways and restoring skin barrier function.
- * Research involved both in vitro (human keratinocytes) and in vivo (mice) models, showing that Magnoliae flos may provide a promising alternative therapy by reducing inflammation.
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- * A study on beagle dogs with meniscectomy and cranial cruciate ligament transection (CCLx) tested a modified-release formulation of SKI306X (SKCPT) to evaluate its effectiveness in managing arthritis.
- * Results showed that SKCPT significantly improved measures of gait and inflammation, and the 300 mg formulation was the most effective, indicating it could be a promising approach for OA management and addressing the disease itself.
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- Collagen is a key protein that helps with skin wounds and osteoarthritis, with fish collagen (FC) emerging as a safer alternative to mammalian sources like bovine and porcine collagens due to potential risks.
- FC is commonly found in skincare products for its health benefits, including wrinkle reduction, UV protection, and wound healing, but its effects on atopic dermatitis (AD) have not been studied until now.
- Research shows that FC can significantly improve symptoms of AD by reducing inflammation, restoring skin barrier function, and aiding immune response through various administration methods (oral, topical, or both).
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- Mitoquinone (MitoQ) is a targeted antioxidant that has potential benefits for treating benign prostatic hyperplasia (BPH) by inhibiting cell growth and reducing harmful mitochondrial reactive oxygen species (ROS).
- The study revealed that MitoQ works by blocking the androgen receptor (AR) and NLRP3 signaling pathways, which are linked to cell proliferation in prostate epithelial cells.
- Furthermore, MitoQ was found to reduce prostate enlargement and showed anti-proliferative effects in rat models of BPH, indicating its promising role as a therapeutic agent for this condition.
Anti-obesity effect of Lythri herba water extracts in vitro and in vivo.
J Ethnopharmacol
December 2023
Article Synopsis
- Lythrum salicaria L., known as purple loosestrife, has a history of medicinal use for internal issues and contains beneficial phytochemicals like orientin, which exhibit various health properties.
- The study aimed to investigate the anti-obesity effects of Lythri Herba, the plant's aerial part, using both cell cultures and high-fat diet-induced mouse models.
- Results indicated that Lythri Herba water extracts significantly reduced fat accumulation in cells and prevented weight gain in mice, primarily by inhibiting key enzymes involved in fat production.
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- Obesity leads to ongoing inflammation in fat tissue, and the study explores the use of Apocynin (APO) to combat this issue by reducing weight gain and associated inflammation.
- Mice given 10 mg/kg of APO showed a significant reduction in fat tissue mass compared to those treated with 20 mg/kg of Orlistat (Orli), along with positive changes in protein markers related to fat metabolism.
- APO not only lessened inflammatory markers in fat tissue but also demonstrated a more pronounced effect against inflammation than Orli, suggesting it could be a viable option for treating obesity-related inflammatory diseases.
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- Many common pain management drugs, like acetaminophen and opioids, have side effects that can't be ignored, prompting researchers to explore new combinations for more effective treatments.
- The study focused on DW-1021, a combination of the NSAID pelubiprofen and the opioid tramadol, to see if it could provide better pain relief and anti-inflammatory effects compared to using either drug alone.
- Results showed that DW-1021 had strong pain-relieving effects and was particularly effective in reducing inflammation, suggesting it could be a promising new option for treating pain and inflammation.
Article Synopsis
- Apocynin (Apo) is an NADPH oxidase inhibitor studied for its potential effects on benign prostatic hyperplasia (BPH), a condition linked to inflammation and hormone imbalance.
- The study aims to understand how androgen signaling and oxidative stress relate to BPH and to evaluate Apo's ability to prevent or treat this condition.
- Results showed that Apo reduced prostate enlargement, inflammation, and oxidative stress in BPH models by modulating specific signaling pathways and promoting antioxidant defenses while requiring androgen receptor involvement for its effects.
Article Synopsis
- Excessive activation of TGF-β1 worsens benign prostatic hyperplasia (BPH) by promoting cell transformation and differentiation.
- Hesperidin (HSP), a citrus-derived flavanone, shows potential anti-cancer properties and may also diminish BPH effects, although previous studies on this aspect are limited.
- Research confirmed that HSP reduces prostate cell growth and inflammation in BPH models by inhibiting TGF-β1 activation and regulating associated signaling pathways, suggesting it could be an effective treatment for BPH.