Publications by authors named "Hyo- Jeong Ahn"
Background: Atrial fibrillation (AF) is associated with increased risks of adverse events including stroke and all-cause death. Understanding the pattern of causes of death (COD) with the relative risks in patients with AF compared to the non-AF population is essential in planning optimal care for patients with AF. We aimed to analyze the COD and its relative risks in patients with AF, using a nationwide population-based cohort.
View Article and Find Full Text PDFBackground And Objectives: Evidence remains limited on the real-world prescription of very low-dose oral anticoagulation among frail patients with atrial fibrillation (AF). We described the practice patterns, effectiveness, and safety of very low-dose edoxaban (15 mg once daily).
Methods: Patients with AF prescribed edoxaban 15 mg once daily in 2 tertiary hospitals between 2016 and September 2022 were included.
Article Synopsis
- This study investigates the difficulty of obtaining ECGs in patients with paroxysmal supraventricular tachycardia and explores using deep learning to classify types of tachycardia based on sinus rhythm ECGs.
- Utilizing a modified deep learning model on data from 833 patients with AVNRT and 346 with concealed AVRT, the study found that pre-training the model improved classification performance significantly.
- The results indicate that while deep learning can help differentiate between AVNRT and concealed AVRT using sinus rhythm ECGs, the performance is still modest, suggesting room for further improvement in non-invasive diagnoses.
Feature attribution methods can visually highlight specific input regions containing influential aspects affecting a deep learning model's prediction. Recently, the use of feature attribution methods in electrocardiogram (ECG) classification has been sharply increasing, as they assist clinicians in understanding the model's decision-making process and assessing the model's reliability. However, a careful study to identify suitable methods for ECG datasets has been lacking, leading researchers to select methods without a thorough understanding of their appropriateness.
View Article and Find Full Text PDFBackground: Clustering lifestyle risk behaviors is important for predicting cardiovascular disease risk. However, it is unclear which behavior mediates other ones to influence cardiovascular disease risk. We aimed to assess the causal inference of each lifestyle risk behavior for the atherosclerotic cardiovascular disease (ASCVD) risk of the general population.
View Article and Find Full Text PDFAims: To investigate plasma apixaban concentrations and thrombin generation assay (TGA) parameters across different apixaban doses in atrial fibrillation patients who had dose-reduction criteria for apixaban.
Methods: This observational study included 374 patients (mean age 75.6 ± 7.
Background: Data on off-label reduced dose risk among patients with atrial fibrillation (AF) who qualify for a single-dose reduction of apixaban is scarce.
Objectives: We prospectively assessed apixaban dosing and clinical characteristics in AF patients meeting a dose reduction criterion.
Methods: The multicentre, prospective cohort study, the efficAcy and Safety of aPixaban In REal-world practice in Korean frail patients with AF (ASPIRE), encompasses patients with AF who met the criteria for a single-dose reduction of apixaban and were given varying doses of apixaban, either the on-label standard dose or the off-label reduced dose.
Article Synopsis
- Renal function is essential in determining the appropriate dosage of oral anticoagulants for atrial fibrillation patients and is linked to stroke and bleeding risks.
- The study analyzed 5,126 AF patients with marginal renal function over two years, categorizing them into maintained, improved, and worsened renal function groups based on eGFR changes.
- Results indicated that patients with worsening renal function faced significantly higher risks of major bleeding, end-stage renal disease, all-cause mortality, and overall adverse clinical outcomes compared to those who maintained their renal function.
The optimal anesthetic agent for radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) and its impact on the recovery profiles remain uncertain. We compared the recovery and hemodynamic parameters between the remimazolam-flumazenil and propofol groups during RFCA. Patients were randomized into the remimazolam-flumazenil and propofol groups.
View Article and Find Full Text PDFBackground: Patients with hypertension are at a high risk of atrial fibrillation (AF). Recent research has indicated the varying effects of antihypertensive medications on developing AF.
Objectives: We investigated the relationship between different types of antihypertensive medications and the risk of AF occurrence.
Background: While treatment interruption of non-vitamin K antagonist oral anticoagulants (NOACs) for elective surgery or procedures among patients with atrial fibrillation (AF) is becoming more prevalent, there remains insufficient evidence regarding the optimal perioperative management of NOACs, particularly procedures with minor bleeding risks.
Objective: This study aims to evaluate the safety and effectiveness of a simplified, standardized protocol for perioperative management of direct factor Xa inhibitors in patients, with AF undergoing procedures associated with minor bleeding risk.
Methods: This multicenter, prospective single-arm registry study plans to enroll patients undergoing procedures with minor bleeding risk who were prescribed direct factor Xa inhibitors for AF.
Background: The association between alcohol consumption and the risk of sudden cardiac death and/or fatal ventricular arrhythmia remains controversial.
Objective: We analyzed the association between alcohol consumption, genetic traits for alcohol metabolism, and the risk of sudden cardiac death and/or fatal ventricular arrhythmia.
Methods: We identified 397,164 individuals enrolled between 2006 and 2010 from the UK Biobank database and followed them until 2021.
Article Synopsis
- Cryoablation is a safe and effective treatment for atrial fibrillation (AF), but its outcomes may vary by body mass index (BMI) in patients, especially in Asians.
- In a study involving 2,648 patients, underweight individuals had a higher recurrence rate of AF after treatment compared to those with a normal BMI, along with a greater risk of complications like transient phrenic nerve palsy.
- These findings suggest that underweight patients require special attention during and after cryoablation due to increased risks of both AF recurrence and procedural complications.
Background: Diabetes mellitus (DM) duration affects incident atrial fibrillation (AF) risk; the effect of physical activity on mitigating AF risk related to varying DM duration remains unknown. We assessed the effect of physical activity on incident AF in patients with DM with respect to known DM duration.
Methods: Patients with type 2 DM who underwent the Korean National Health Insurance Service health examination in 2015-2016 were grouped by DM duration: new onset and < 5, 5-9, and ≥ 10 years.
Background: Wearable electrocardiogram (ECG) monitoring devices are used worldwide. However, data on the diagnostic yield of an adhesive single-lead ECG patch (SEP) to detect premature ventricular complex (PVC) and the optimal duration of wearing an SEP for PVC burden assessment are limited.
Objective: We aimed to validate the diagnostic yield of an SEP (mobiCARE MC-100, Seers Technology) for PVC detection and evaluate the PVC burden variation recorded by the SEP over a 3-day monitoring period.
Objective: Data on cardiovascular outcomes according to objectively measured physical activity (PA) in patients with atrial fibrillation (AF) are scarce. This study explored the associations between PA derived from wrist-worn accelerometers and the risk of death, incident heart failure (HF), and incident stroke in patients with AF.
Methods: From 37 990 patients with AF in UK Biobank, 2324 patients with accelerometer data were included.
Background: The association between neuroticism and atrial fibrillation (AF) remains unknown.
Objectives: This study aimed to assess the epidemiological and causal relationships between neuroticism and AF.
Methods: Individuals without AF history were selected From the UK Biobank nationwide prospective cohort study.
Article Synopsis
- The study focuses on how antithrombotic drugs are prescribed and their clinical outcomes in patients with atrial fibrillation (AF) who have experienced an acute ischemic stroke (IS), highlighting a gap in optimal treatment data.
- A retrospective review of 918 patients was conducted, examining their clinical profiles, stroke causes, and changes in medication from hospitalization to outpatient settings, with a notable shift in antithrombotic therapy after discharge.
- Results showed that while many patients were prescribed oral anticoagulation (OAC), a significant number (11.3%) received no OAC post-stroke, and those on antiplatelet therapy alone had a higher risk of negative clinical outcomes compared to those on OAC alone
Background And Aims: Both clonal haematopoiesis of indeterminate potential (CHIP) and atrial fibrillation (AF) are age-related conditions. This study investigated the potential role of CHIP in the development and progression of AF.
Methods: Deep-targeted sequencing of 24 CHIP mutations (a mean depth of coverage = 1000×) was performed in 1004 patients with AF and 3341 non-AF healthy subjects.
Article Synopsis
- Patients with atrial fibrillation (AF) on direct oral anticoagulants (DOAC) face a serious risk of upper gastrointestinal bleeding (UGIB), and this study examines the effectiveness of preventive proton pump inhibitors (PPIs) to mitigate that risk.
- The research analyzed data from 165,624 AF patients treated with DOAC between 2015 and 2020, employing a propensity score method to compare outcomes between those using PPIs and those who weren't.
- Results showed that PPI use significantly lowered hospitalization rates for UGIB, particularly benefiting older patients and those with higher risk factors, indicating that PPIs should be considered for high-risk individuals on DOAC therapy.
Background: The predictive relationship between mild-to-moderate alcohol consumption and the risk of incident atrial fibrillation (AF) remains controversial.
Objective: We investigated whether the relationship between alcohol consumption and the risk of incident AF could be associated with the genetic predisposition to alcohol metabolism.
Methods: A total of 399,329 subjects with genetic data from the UK Biobank database, enrolled between 2006 and 2010, were identified and followed for incident AF until 2021.
Aims: We evaluated the impact of early rhythm control (ERC) on diabetes-related complications and mortality in subjects with type 2 diabetes mellitus (T2DM) and atrial fibrillation (AF).
Methods: This observational cohort study based on the Korean National Health Insurance Service claims database from 2009 to 2016, divided newly diagnosed AF patients with T2DM into ERC or usual care groups based on receiving rhythm control treatment within 1 year of AF diagnosis. The primary outcome was ischemic stroke, and the secondary outcomes were macro/microvascular complications, and all-cause death.
Article Synopsis
- - The study investigates a new laparoscopic approach to renal denervation (RDN) and its effects on reducing atrial fibrillation (AF) episodes in pigs.
- - Swine were divided into groups to assess changes in atrial effective refractory period (AERP) and AF inducibility after RDN compared to a sham procedure, with vagal nerve stimulation (VNS) also tested.
- - Results showed that laparoscopic RDN significantly increased AERP and decreased both the inducibility and duration of AF episodes, suggesting its potential effectiveness for future cardiac treatments.