Hypolipemic effect of water extracts of Picrorrhiza rhizoma in PX-407 induced hyperlipemic ICR mouse model with hepatoprotective effects: a prevention study.

The preventive hypolipemic effect of water extract of Picrorrhiza rhizoma (PR) was observed in Poloxamer (PX)-407 induced hyperlipemic mice with their hepatoprotective effects. Doses of 50, 100 and 200 mg/kg of PR extracts were given orally once a day for 12 weeks initiated with intraperitoneal injection of PX-407 (0.5 g/kg), and changes in body weight and gains, liver weight, serum aspartate transferase (AST) and alanine transferase (ALT) levels were monitored with serum low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride and total cholesterol levels.